Evidence map›Paper›PMID 40726795›Full record

ArticleACS central science2025

Green-Light-Activatable Penicillin for Light-Dependent Spatial Control of Bacterial Growth, Biofilm Formation, and

Albert Marten Schulte, Jorrit W A Schoenmakers, Marleen van Oosten, Paul C Jutte, Jan Maarten van Dijl, Wiktor Szymanski, Ben L Feringa

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In one paragraph

Article in ACS central science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Albert Marten SchulteCentre for Systems Chemistry, Stratingh Institute for Chemistry, Faculty for Science and Engineering, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands.ORCID https://orcid.org/0000-0001-9948-6132
Jorrit W A SchoenmakersDepartment of Medical Microbiology and Infection Prevention, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands.
Marleen van OostenDepartment of Medical Microbiology and Infection Prevention, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands.
Paul C JutteDepartment of Orthopaedics, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands.
Jan Maarten van DijlDepartment of Medical Microbiology and Infection Prevention, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands.ORCID https://orcid.org/0000-0002-5688-8438
Wiktor SzymanskiCentre for Systems Chemistry, Stratingh Institute for Chemistry, Faculty for Science and Engineering, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands.ORCID https://orcid.org/0000-0002-9754-9248
Ben L FeringaCentre for Systems Chemistry, Stratingh Institute for Chemistry, Faculty for Science and Engineering, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands.ORCID https://orcid.org/0000-0003-0588-8435

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Our ability to prevent, treat, and cure bacterial infections is nowadays seriously threatened by the rise of (multidrug) antimicrobial resistance (AMR), and novel molecular approaches in the antibacterial arsenal are urgently needed. To fight the development of AMR, the field of photopharmacology aims to develop photoresponsive antimicrobials allowing for noninvasive activation of the drug only at the site needed, with spatiotemporal precision, reducing the bacterial exposure to the active antimicrobial in the environment. This study reports the development and application for the first time of a green-light-activatable variant of penicillin (

Identifiers

PMID40726795
PMCPMC12291127

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.