Evidence map›Paper›PMID 40726789›Full record

ArticleACS central science2025

Asymmetric Total Synthesis of 4,9,10-Trihydroxyguaia-11(13)en-12,6-olide and Discovery of Its Anticancer Activity against Atypical Teratoid Rhabdoid Tumor.

Hyejin Lee, Hongjun Jang, Hwan Myung, Angela Rivera, Anna F Averette, Joseph Heitman, Jiyong Park, Deukjoon Kim, Hyoungsu Kim, Jiyong Hong

Abstract read
In one paragraph

Article in ACS central science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hyejin LeeDepartment of Chemistry, Duke University, Durham, North Carolina 27708, United States.
Hongjun JangDepartment of Chemistry, Duke University, Durham, North Carolina 27708, United States.ORCID https://orcid.org/0000-0003-2996-9870
Hwan MyungDepartment of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea.ORCID https://orcid.org/0009-0002-9403-0069
Angela RiveraDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina 27710, United States.
Anna F AveretteDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina 27710, United States.
Joseph HeitmanDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina 27710, United States.ORCID https://orcid.org/0000-0001-6369-5995
Jiyong ParkCenter for Catalytic Hydrocarbon Functionalizations, Institute for Basic Science (IBS), Daejeon 34141, Republic of Korea.ORCID https://orcid.org/0000-0002-3225-4510
Deukjoon KimCollege of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.ORCID https://orcid.org/0000-0003-4079-8734
Hyoungsu KimCollege of Pharmacy and Research Institute of Pharmaceutical Science and Technology (RIPST), Ajou University, Suwon 16499, Republic of Korea.ORCID https://orcid.org/0000-0002-2774-8727
Jiyong HongDepartment of Chemistry, Duke University, Durham, North Carolina 27708, United States.ORCID https://orcid.org/0000-0002-5253-0949

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The guaianolide family of sesquiterpene lactones is known for its distinctive structural features and diverse biological activities. 4,9,10-Trihydroxyguaia-11(13)-en-12,6-olide, with an underdetermined absolute stereochemistry (

Identifiers

PMID40726789
PMCPMC12291133

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.