ArticleACS central science2025
Design and Development of an Organocatalyst for Light Accelerated Amide and Peptide Synthesis.
Yiping Li, Jingyue Li, Zhouming Shen, Haoyu Kuang, Quan Zuo, Guangjun Bao, Jingman Ni, Wangsheng Sun, Rui Wang
Abstract read
In one paragraphArticle in ACS central science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
9 authors.
Yiping LiKey Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences & Research Unit of Peptide Science, Chinese Academy of Medical Sciences, 2019RU066, Lanzhou University, Lanzhou 730000, Gansu, P. R. China.ORCID https://orcid.org/0009-0009-9665-858X Jingyue LiKey Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences & Research Unit of Peptide Science, Chinese Academy of Medical Sciences, 2019RU066, Lanzhou University, Lanzhou 730000, Gansu, P. R. China.
Zhouming ShenKey Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences & Research Unit of Peptide Science, Chinese Academy of Medical Sciences, 2019RU066, Lanzhou University, Lanzhou 730000, Gansu, P. R. China.
Haoyu KuangKey Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences & Research Unit of Peptide Science, Chinese Academy of Medical Sciences, 2019RU066, Lanzhou University, Lanzhou 730000, Gansu, P. R. China.
Quan ZuoState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, P. R. China.ORCID https://orcid.org/0000-0002-4451-3380 Guangjun BaoKey Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences & Research Unit of Peptide Science, Chinese Academy of Medical Sciences, 2019RU066, Lanzhou University, Lanzhou 730000, Gansu, P. R. China.
Jingman NiKey Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences & Research Unit of Peptide Science, Chinese Academy of Medical Sciences, 2019RU066, Lanzhou University, Lanzhou 730000, Gansu, P. R. China.ORCID https://orcid.org/0000-0002-8728-1268 Wangsheng SunKey Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences & Research Unit of Peptide Science, Chinese Academy of Medical Sciences, 2019RU066, Lanzhou University, Lanzhou 730000, Gansu, P. R. China.ORCID https://orcid.org/0000-0001-5277-3329 Rui WangKey Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences & Research Unit of Peptide Science, Chinese Academy of Medical Sciences, 2019RU066, Lanzhou University, Lanzhou 730000, Gansu, P. R. China.ORCID https://orcid.org/0000-0002-4719-9921 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
The catalytic methods for amide and peptide synthesis have long been recognized as some of the most pressing challenges in industry and academia. Designing more attractive catalysts is crucial to addressing these challenges. Herein, we report a simple organocatalyst, named Cat-Se, for the direct synthesis of amides and peptides. The catalyst can simultaneously avoid many application barriers, thereby providing a good boost to applied research in the field. It can rapidly catalyze various carboxylic acids and amines to form amides in high yields under mild light irradiation conditions without any undesirable operations. The method exhibits high selectivity and maintains stereochemical integrity during peptide synthesis. Significantly, Cat-Se also shows effectiveness in peptide fragment condensation and solid-phase peptide synthesis, making it an attractive method for peptide drug synthesis.
Identifiers
PMID40726784
PMCPMC12291130
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390