ArticleJournal of pain research2025
Causal Relationship Between Migraine and Postpartum Depression: A Two-Sample Bidirectional Mendelian Randomization Study.
Article in Journal of pain research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Immune Cells Mediate the Causal Pathway Linking Multisite Chronic Pain to Asthma: A Mediation Mendelian Randomization Study.Journal of pain research · 2025Article
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Authors and funding
3 authors.
Funding
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Abstract
Background: The possible causative relationship between migraine and postpartum depression (PPD) is examined in this study. Prior research has shown a strong correlation between the two conditions, but the exact cause is unknown. Methods: A bidirectional Mendelian randomization (MR) approach was employed to assess causality, utilizing discovery and replication samples from publicly available genome-wide association study (GWAS) datasets. Causal effects were estimated using the inverse-variance weighted (IVW) method, MR-Egger regression, and three additional MR approaches. Sensitivity analyses, including tests for heterogeneity, horizontal pleiotropy, and leave-one-out analysis, were conducted to evaluate the robustness of the findings. Results: Overall, no significant causal effect of migraine on PPD risk was identified in either the discovery (IVW: OR=1.018; 95% CI=0.928-1.117; P=0.706) or replication analysis (IVW: OR=2.097; 95% CI=0.328-13.409; P=0.434) in forward MR analysis. Similarly, no causal effect of migraine on PPD was observed in female-only analyses. Moreover, reverse MR analysis found no significant causal effect of PPD on migraine risk in discovery (IVW: OR=1.036; 95% CI=0.999-1.075; P=0.057) or replication (IVW: OR=1.001; 95% CI=1.000-1.002; P=0.274) analysis, and no causal effect was observed in female-only analyses. No evidence of heterogeneity or horizontal pleiotropy was detected in sensitivity tests. Conclusion: The current MR study indicates no significant causal relationship between migraine and PPD.
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