ArticleJournal of family medicine and primary care2025
Levothyroxine therapy and its impact on serum lipids: Addressing dyslipidemia in hypothyroidism.
Article in Journal of family medicine and primary care, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background and Objective: The major goal of this study was to analyse the influence of levothyroxine medication on serum lipid levels in individuals with hypothyroidism, as well as its efficacy in controlling dyslipidemia caused by thyroid hormone deficiencies. This method provides a complete assessment of therapy efficacy and aids in identifying factors that may influence treatment results. Methodology: This prospective observational study, conducted from September 2019 to October 2020 at Shri Shiv Prasad Gupt Divisional District Hospital in Varanasi, India, included 150 patients with newly diagnosed hypothyroidism. A predesigned proforma was used in the study to collect demographic and medical history information. The data were analysed using SPSS version 23. Results: The study of 150 newly diagnosed hypothyroidism patients, predominantly aged 31-40 years and with a significant female predominance (95.4%), found a notable age and gender distribution in subclinical versus overt hypothyroidism. Subclinical cases were all female and concentrated in the 31-40 age group, while overt hypothyroidism was more evenly distributed, with a higher prevalence in the same age group and extending to older ages. TSH levels were significantly higher in overt hypothyroidism (45.1 ± 30.4 μU/mL) compared to subclinical hypothyroidism (8.6 ± 0.82 μU/mL, Conclusion: The study found that levothyroxine therapy significantly improved lipid profiles and reduced TSH levels in both subclinical and overt hypothyroidism. Despite these positive outcomes, the small sample size and short duration suggest the need for further research with a larger cohort and longer follow-up to validate and expand on these findings.
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