ArticleJournal of family medicine and primary care2025
Association of QTc prolongation with liver function test and complications in patients with cirrhosis: An observational study.
Article in Journal of family medicine and primary care, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Cirrhotic cardiomyopathy is a cardiac abnormality due to hepatic cirrhosis, which presents as a serious electrocardiographic complication and often the patient is asymptomatic. The objective of our study was to find the ECG changes in patients with various aetiologies of cirrhosis and correlate them with their respective LFT parameters. Materials and Methodology: We assessed the QTc interval in patients of various aetiologies of liver cirrhosis and correlated them with the prevalence of complication of cirrhosis, such as portal hypertension, splenomegaly, and ascites. Furthermore, we correlated the LFT parameters with their respective QTc interval. Results: Our study evaluated 300 patients of multiple aetiologies of cirrhosis, such as ALD, NASH, DCLD, AIH, HCC, HA, Hep-B, and Wilson's disease. Prolonged QTc was observed in 194 (64.66%) patients. QTc prolongation was most prevalent in DCLD patients. The association of complication including portal hypertension, splenomegaly, and ascites with prolonged QTc were all statistically significant ( Conclusion: Prolonged QTc interval is frequently observed as the ECG abnormality in patients with cirrhosis. QT prolongation correlates with elevated LFTs and cirrhotic complications.
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