ArticleFrontiers in neurology2025
Analysis of the correlation between peripheral blood inflammatory markers and imaging burden of cerebral small vessel disease.
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association between neutrophil-to-lymphocyte ratio and cerebral small vessel disease: a systematic review and meta-analysis.Frontiers in neurology · 2026Pooled it
- Association of composite biomarkers with imaging burden in cerebral small vessel disease.Lipids in health and disease · 2026Article
- Triglyceride-glucose index is associated with cerebral small vessel disease-related motor impairment in Parkinson's disease: a mediation analysis.Frontiers in aging neuroscience · 2026Article
- Relationship between insomnia and cognitive function in elderly Chinese cerebral small vessel disease patients: mediating effect of neutrophil-to-lymphocyte ratio.Frontiers in psychiatry · 2026Article
- Development of a clinical prediction model for inflammatory biomarkers and enlarged basal ganglia perivascular spaces using SHAP analysis: feature selection and model interpretation.Frontiers in neurology · 2025Article
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Authors and funding
12 authors.
Funding
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Abstract
Background: The purpose of this study is to explore the relationship between peripheral blood inflammation-related indicators, such as neutrophil count (NC), neutrophil-to-lymphocyte ratio (NLR), and systemic immune-inflammation index (SII), and the imaging burden and subtypes of cerebral small vessel disease (CSVD). Methods: Gather relevant indicators from the population who underwent physical examinations at the Affiliated Hospital of Jining Medical University between 2018 and 2023. Evaluate the total burden and various imaging markers according to the comprehensive burden score of cerebral small vessel disease (CSVD). Employ logistic regression analysis to investigate the correlation between neutrophil count (NC), neutrophil-to-lymphocyte ratio (NLR), and systemic immune-inflammation index (SII) with the overall burden of CSVD and its distinct markers. Results: A cohort of 12,478 patients who underwent physical examinations was initially assembled. Following the application of specific inclusion and exclusion criteria, the study included 1,526 patients diagnosed with cerebral small vessel disease (CSVD) and 6,955 6,955 individuals serving as controls. Logistic regression analysis indicated no significant association between the overall burden scores of CSVD and systemic immune-inflammation index (SII), neutrophil-to-lymphocyte ratio (NIR), or neutrophil count (NC). Nonetheless, within the spectrum of imaging markers for CSVD, a significant correlation was identified between deep microbleeds and SII ( Conclusion: This analysis reveals a correlation between NC and SII with CSCD (especially Deep cerebral microbleeds and EPVS), which has warning implications for the prevention of CSVD.
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