ArticleNeuropsychiatric disease and treatment2025
Role of LncRNA in Trauma Susceptibility and Resilience to Post-Traumatic Stress Disorder (PTSD): A Pilot Study in the African American Population.
Article in Neuropsychiatric disease and treatment, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Epigenetic mechanisms in traumatic brain injury: a focus on astrocytes and therapeutic implications.Journal of neuroinflammation · 2026Review
- From classic circuits to novel mechanisms: How lncRNA, neuroinflammation, and iPSC models address the translational crisis in PTSD research.Comprehensive psychoneuroendocrinology · 2026Review
- A genome-wide association study of post-traumatic stress disorder in traumatised Chinese populations.General psychiatry · 2026Article
- Comprehensive Explorations and Preliminary Experimental Verification of RNA Modification-Related Diagnostic Markers in the Subtype Classification of Peripheral Blood-Derived Mononuclear Cells Derived from Post-Traumatic Stress Disorder Patients.Diseases (Basel, Switzerland) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
Abstract
Purpose: Childhood adversities are associated with the development of post-traumatic stress disorder (PTSD). However, not all individuals exposed to severe trauma develop psychopathology, underscoring the need for a better understanding of the molecular pathophysiology underlying vulnerability to PTSD. Evidence suggests that the peripheral olfactory system, which is accessible in the nose, regulates the structure and function of olfactory regions relevant to stress biology. Long non-coding RNAs (lncRNAs) control transcriptional regulation via epigenetic mechanisms, and since these elements are sensitive to environmental inputs, they may play a crucial role in diseases like PTSD, which are highly dependent on environmental experiences. This study aims to identify lncRNAs in the olfactory mucosa associated with vulnerability and resilience to PTSD in African American populations. Patients and Methods: Thirty-eight adult residents in the Washington DC metropolitan region, aged 18-50 years were recruited based on a history of exposure to trauma during childhood. Participants were divided into three groups: those who experienced childhood trauma and developed PTSD, those with similar trauma but did not develop PTSD, and a control group who did not experience childhood trauma. Olfactory mucosa samples were collected through nasal brushings, and neurobehavioral assessments were conducted. RNA sequencing was performed to facilitate lncRNA-based analysis, exploring differentially expressed lncRNAs among the specified groups. Results: Two lncRNAs, CYP1B1-AS1 and SLC7A11-AS1, known for their neuroprotective and anti-inflammatory functions, were significantly elevated in the PTSD group compared to the non-trauma-exposed controls. Ingenuity Pathway Analysis of the differentially expressed lncRNAs suggests their potential involvement in NFAT5-mediated inflammatory cascades, indicating a possible biological mechanism underlying PTSD vulnerability. Conclusion: PTSD may be associated with epigenetic modifications of inflammatory and immunoregulatory pathways in the olfactory system. Further evaluation of the relationship between these differentially expressed lncRNAs and PTSD should be conducted with larger samples and more diverse cohorts.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.