Evidence map›Paper›PMID 40726517›Full record

ArticleFrontiers in hematology2024

Case Report: Childhood Erythrocytosis due to Hypermanganesemia Caused by Homozygous

Tiziana Coppola, Hannah Hughes, Paul Finch, Joshua Hess, Steve Wu, Carlos Prada, Alexander G Miethke, Wenying Zhang, Theodosia A Kalfa

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in hematology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Removal of Toxic Metabolites-Chelation: Manganese Disorders.Journal of inherited metabolic disease · 2025
    Review
  2. Review
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tiziana CoppolaCancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States.
Hannah HughesMarshall University, Edwards Comprehensive Cancer Center, Huntington, West Virginia, United States.
Paul FinchMarshall University, Edwards Comprehensive Cancer Center, Huntington, West Virginia, United States.
Joshua HessMarshall University, Edwards Comprehensive Cancer Center, Huntington, West Virginia, United States.
Steve WuDivision of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States.
Carlos PradaDivision of Genetics, Genomics, and Metabolism, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, 60611, USA.
Alexander G MiethkeDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States.
Wenying ZhangDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States.
Theodosia A KalfaCancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States.

Funding

The Role of Erythroblastic Islands in Anemia of InflammationR01HL152099 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI BLANC, LIONEL, KALFA, THEODOSIA ANASTASIOS · 2020 to 2023
$2.5M
Rho GTPases in Terminal Erythroid MaturationR01HL116352 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI KALFA, THEODOSIA ANASTASIOS · 2012 to 2015
$1.5M
NHLBI NIH HHS R01 HL116352NHLBI NIH HHS R01 HL152099
6 · The paper itself

Abstract

We present a rare case of erythrocytosis due to a homozygous

Indexed as

case reporterythrocytosishypoxia-sensing pathwaySLC30A10trientine

Identifiers

PMID40726517
PMCPMC12302851

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.