ReviewJournal of the Endocrine Society2025
Physiological Functions and Pathological Roles of PXR.
Review in Journal of the Endocrine Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Structure-based machine learning model for discovering pregnane X receptor (PXR) agonists and biological activity validation.Archives of toxicology · 2026Article
- Selective statin therapy and nasal staphylococcal colonisation: a retrospective case-control study.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Article
- Coenzyme Q10 protects against atorvastatin-induced hepatotoxicity via attenuation of oxidative stress and functional modulation of CYP3A1.BMC pharmacology & toxicology · 2026Article
- Metabolic Disruption and Steatosis Induced by Drinking Water Disinfection Byproducts in HepG2 and HUH7 Cells.Toxics · 2026Article
- Gut microbiota-derived tryptophan metabolites: molecular mechanisms, nutritional strategies and implications for swine health.Frontiers in veterinary science · 2026Review
- Bisphenol F and Steatotic Liver Disease: Resolving the PXR Paradox Through Stress Pathway Mechanisms.Biomedicines · 2025Review
- Recent advances in gut microbiota metabolite regulation of hepatic pregnane X receptor.Frontiers in immunology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
The pregnane X receptor (PXR, NR1I2), a member of the nuclear receptor superfamily, mainly acts as a ligand-activated transcription factor. PXR is predominantly expressed in the liver and intestines, though it is also present at lower levels in various other tissues. PXR is known for its critical role in regulating the metabolism of various chemical substances, including dietary, xenobiotic, and endogenous compounds. As a master regulator of detoxification pathways, PXR modulates the expression of drug-metabolizing enzymes and transporters, contributing to the clearance of potentially harmful compounds. Beyond this classic role, emerging evidence highlights a broader role for PXR on metabolic homeostasis and its involvement in several physiological processes and diseases. This review provides a comprehensive overview of PXR functions across several key metabolic pathways. PXR influences glucose homeostasis by modulating the expression of genes involved in glucose production and insulin sensitivity, highlighting its important role in glucose regulation. PXR regulates the synthesis, breakdown, and transport of lipids, and regulates the expression of genes involved in fatty acid oxidation and cholesterol homeostasis. PXR is involved in inflammatory diseases by modulating the expression of inflammatory cytokines and immune responses, indicating that PXR is a potential target for therapeutic interventions in inflammatory disorders. Furthermore, we discuss PXR function on the regulation of vitamin, bone, and bile acid metabolism.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.