Evidence map›Paper›PMID 40726352›Full record

ArticleUltrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology2025

Longitudinal assessment of intravillous arterioles in normal pregnancy using superb microvascular imaging.

R Horgan, E Sinkovskaya, G Saade, E Kalafat, A Heeze, A Abuhamad

Abstract read
In one paragraph

Article in Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

R HorganDepartment of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Macon & Joan Brock Virginia Health Sciences, Old Dominion University, Norfolk, VA, USA.ORCID 0000-0002-2752-4061
E SinkovskayaDepartment of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Macon & Joan Brock Virginia Health Sciences, Old Dominion University, Norfolk, VA, USA.
G SaadeDepartment of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Macon & Joan Brock Virginia Health Sciences, Old Dominion University, Norfolk, VA, USA.
E KalafatDepartment of Obstetrics and Gynecology, School of Medicine, Koc University, Istanbul, Turkey.ORCID 0000-0003-0658-138X
A HeezeDepartment of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Macon & Joan Brock Virginia Health Sciences, Old Dominion University, Norfolk, VA, USA.
A AbuhamadDepartment of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Macon & Joan Brock Virginia Health Sciences, Old Dominion University, Norfolk, VA, USA.

Funding

Novel Tools for the Noninvasive Evaluation of the Human PlacentaR01HD086313 · NICHD · EASTERN VIRGINIA MEDICAL SCHOOL · PI ABUHAMAD, ALFRED Z, SAADE, GEORGE R. · 2015 to 2018
$2.7M
NICHD NIH HHS R01 HD086313NIH HHS HD 086313-01
6 · The paper itself

Abstract

objectiveTo use superb microvascular imaging (SMI) to longitudinally evaluate blood flow in intravillous arterioles (IVA) in pregnancy, and to develop reference ranges for IVA pulsatility index (PI) and peak systolic velocity (PSV) from 12 to 38 weeks' gestation.

methodsThe data for this study were obtained from the National Institutes of Health-funded Human Placenta Project. Eligible for inclusion were women aged 18-35 years, with a body mass index of < 30 kg/m

resultsA total of 90 women fulfilled the study criteria. IVA-PI decreased throughout pregnancy from a mean ± SD of 1.04 ± 0.23 in the first trimester (at 12-13 weeks) to 0.75 ± 0.10 in the late third trimester (at 36-37 weeks). Mean IVA-PSV increased from 5.97 ± 1.47 cm/s at 12-13 weeks to 12.65 ± 4.19 cm/s at 28-29 weeks, and then plateaued throughout the third trimester, to 13.09 ± 4.64 cm/s at 36-37 weeks. UA-PI decreased progressively throughout pregnancy, from 1.49 ± 0.22 at 16-17 weeks to 0.89 ± 0.18 at 36-37 weeks. Reference ranges for IVA-PI and IVA-PSV from 12 to 38 weeks' gestation were developed.

conclusionPlacental IVA blood flow can be visualized and quantified from early gestation in normal pregnancies using SMI. © 2025 The Author(s). Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.

Indexed as

PlacentaPlacental CirculationUltrasonography, PrenatalAdolescentAdultArteriolesBlood Flow VelocityFemaleGestational AgeHumansLongitudinal StudiesPregnancyPulsatile FlowReference ValuesUmbilical ArteriesYoung AdultDopplerintravillous arterioleplacentasuperb microvascular imagingumbilical artery

Identifiers

PMID40726352
PMCPMC12313223

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.