Evidence map›Paper›PMID 40726181›Full record

ArticleEuropean stroke journal2025

Successful reperfusion for better outcomes in medium vessel occlusion: Penumbral salvage versus infarct volume reduction.

Guangchen He, Tingyu Yi, Jiangshan Deng, Liming Wei, Haitao Lu, Dinglai Lin, Xiaohui Lin, Yan Zhang, Guihua Miao, Da Liang and 3 more

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Article in European stroke journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Guangchen HeDepartment of Radiology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0000-0003-2043-7202
Tingyu YiDepartment of Neurointervention, Zhangzhou Affiliated Hospital of Fujian Medical University, Fujian, China.
Jiangshan DengDepartment of Neurology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Liming WeiDepartment of Radiology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0000-0003-0223-8445
Haitao LuDepartment of Radiology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0000-0002-1772-764X
Dinglai LinDepartment of Neurointervention, Zhangzhou Affiliated Hospital of Fujian Medical University, Fujian, China.
Xiaohui LinDepartment of Neurointervention, Zhangzhou Affiliated Hospital of Fujian Medical University, Fujian, China.
Yan ZhangDepartment of Neurology, The First People's Hospital of Kunshan, Kunshan, Jiangsu Province, China.
Guihua MiaoDepartment of Neurology, The First People's Hospital of Kunshan, Kunshan, Jiangsu Province, China.
Da LiangDepartment of Neurology, The First People's Hospital of Kunshan, Kunshan, Jiangsu Province, China.
Wenhuo ChenDepartment of Neurointervention, Zhangzhou Affiliated Hospital of Fujian Medical University, Fujian, China.
Jingye WangDepartment of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Yueqi ZhuDepartment of Radiology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0000-0001-5476-9075

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe benefits of endovascular thrombectomy (EVT) over medical treatment for medium vessel occlusion (MeVO) remain uncertain. Understanding how vascular reperfusion leads to favorable outcomes is crucial. This study examines whether penumbra salvage and infarct volume reduction quantify EVT benefits in MeVO patients and assesses their impact on clinical improvement post-reperfusion.

methodsWe conducted a multicenter, observational study analyzing MeVO patients who underwent thrombectomy and received multimodal CT imaging from January 2020 to June 2024. EVT efficacy was evaluated by measuring follow-up infarct volume (FIV) on CT scans 24-48 h post-procedure and calculating the penumbra salvage index (PSI). PSI is the ratio of salvaged tissue volume (difference between baseline delay time (DT) >3 s volume and FIV) to baseline DT >3 s volume. Mediation analysis assessed PSI and FIV's contributions to successful reperfusion and functional outcomes.

resultsOf 338 patients, 241 (72%) achieved successful reperfusion. Median FIV was 21 mL (IQR 12-32 mL), and median PSI was 0.68 (IQR 0.50-0.82). Successful reperfusion was linked to a 0.10 increase in PSI (95% CI: 0.05-0.15,

conclusionsIn acute MeVO patients, penumbra salvage significantly mediates the beneficial relationship between reperfusion and excellent clinical outcomes, more so than infarct volume reduction.

Indexed as

CT perfusionfollow-up infarct volumeMedium vessel occlusionpenumbra salvaged indexreperfusion

Identifiers

PMID40726181
PMCPMC12307323

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