ArticleAnalytical chemistry2025
Sensitive Detection and Identification Method of Erythrocyte-like Cells upon Doxorubicin Induced Differentiation with Vibrational Techniques.
Article in Analytical chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Recent advances in Raman probes for multiplexed bioimaging.Inflammation and regeneration · 2025Review
- Raman Spectroscopy of Cell-Free Cervicovaginal Lavage for HPV Lesion Diagnosis: A Pilot Study.International journal of molecular sciences · 2025Article
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Authors and funding
6 authors.
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Abstract
Altered differentiation of blood cell precursors and their clonal expansion occurs in various types of leukemia. One treatment strategy is to induce differentiation into the mature form, which is capable of undergoing apoptosis. It has been found that low doses of doxorubicin (DOX) induce phenotypic and morphological changes in malignant erythroid precursors to erythrocyte-like cells. These are usually studied by time-consuming examination of hemoglobinisation by benzidine staining or glycophorin A expression by Western blot or flow cytometry. As an alternative, we propose an in-depth investigation of DOX-induced erythroid differentiation using Raman spectroscopy and stimulated Raman scattering microscopy, and fast and sensitive classification using the probe for mitochondrial imaging (MitoBADY). Machine learning methods, including Orthogonal Partial Least Squares, Principal Component Analysis, and Multivariate Curve Resolution-Alternating Least Squares, etc., were implemented to extract spectroscopic markers of differentiation from both single spectra and the hyperspectral images.
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