ArticleOncoimmunology2025
Characteristics and significance of γδ T cells in colorectal cancer.
Article in Oncoimmunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- γδ T cells and cancer.The Journal of clinical investigation · 2026Review
- γδ T cells in colorectal and liver cancer.Nature reviews. Gastroenterology & hepatology · 2026Review
- Characterisation of tumor-infiltrating gamma-delta T cells in human colorectal cancer with MHC-I loss.Clinical & translational immunology · 2026Article
- Functional heterogeneity of γδ T cells in colorectal cancer.Frontiers in immunology · 2026Review
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Authors and funding
21 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gamma-delta T cells are a subset of T cells that have features of both innate and adaptive immunity. Their role in cancer remains controversial, since both anti- and protumor functions have been reported. We aimed to shed light on the distinct characteristics of γδ T cells in colorectal cancer (CRC). In two independent cohorts, including 1 687 CRC patients, we identified γδ and αβ T cells with multiplex immunohistochemistry to evaluate their prognostic significance. To further analyze the characteristics of γδ T cells, we utilized single-cell RNA sequencing data of 62 CRC patients. High γδ T cell densities were associated with prolonged survival in both cohorts, and this association was independent of other tumor and patient characteristics in Cohort 1, where the multivariable HR for high (vs. low) γδ T cell density was 0.65 (95% CI 0.47-0.90), while the corresponding HR in Cohort 2 was 0.82 (0.50-1.33). αβ T cells demonstrated a stronger association with longer survival that was independent of other prognostic factors in both cohorts. γδ T cells were enriched in mismatch repair (MMR) deficient and
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