Evidence map›Paper›PMID 40726062›Full record

ArticleEuropean journal of immunology2025

Aging and Viral Evolution Impair Immunity Against Dominant Pan-Coronavirus-Reactive T Cell Epitope.

Lucie Loyal, Karsten Jürchott, Ulf Reimer, Lil Meyer-Arndt, Larissa Henze, Norbert Mages, Jak Kostrzanowski, Bernhard Reus, Maike Mangold, Beate Kruse and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Lucie LoyalSi-M/"Der Simulierte Mensch" a science framework of Technische Universität Berlin and Charité - Universitätsmedizin Berlin, Berlin, Germany.ORCID 0000-0001-5738-4437
Karsten JürchottBerlin Institute of Health (BIH) at Charité - Universitätsmedizin Berlin, Immunomics - Regenerative Immunology and Aging, Berlin, Germany.
Ulf ReimerJPT Peptide Technologies GmbH, Berlin, Germany.
Lil Meyer-ArndtSi-M/"Der Simulierte Mensch" a science framework of Technische Universität Berlin and Charité - Universitätsmedizin Berlin, Berlin, Germany.
Larissa HenzeSi-M/"Der Simulierte Mensch" a science framework of Technische Universität Berlin and Charité - Universitätsmedizin Berlin, Berlin, Germany.
Norbert MagesMax Planck Institute for Molecular Genetics, Berlin, Germany.
Jak KostrzanowskiDepartment of Informatics, School of Engineering and Informatics, University of Sussex, Brighton, UK.
Bernhard ReusDepartment of Informatics, School of Engineering and Informatics, University of Sussex, Brighton, UK.
Maike MangoldSi-M/"Der Simulierte Mensch" a science framework of Technische Universität Berlin and Charité - Universitätsmedizin Berlin, Berlin, Germany.
Beate KruseSi-M/"Der Simulierte Mensch" a science framework of Technische Universität Berlin and Charité - Universitätsmedizin Berlin, Berlin, Germany.
Manuela DingeldeySi-M/"Der Simulierte Mensch" a science framework of Technische Universität Berlin and Charité - Universitätsmedizin Berlin, Berlin, Germany.
Birgit SawitzkiBerlin Institute of Health (BIH) at Charité - Universitätsmedizin Berlin, Immunomics - Regenerative Immunology and Aging, Berlin, Germany.
Janine MichelHighly Pathogenic Viruses, Centre for Biological Threats and Special Pathogens, WHO Reference Laboratory for SARS-CoV-2 and WHO Collaborating Centre for Emerging Infections and Biological Threats, Robert Koch Institute, Berlin, Germany.
Marica GrossegesseHighly Pathogenic Viruses, Centre for Biological Threats and Special Pathogens, WHO Reference Laboratory for SARS-CoV-2 and WHO Collaborating Centre for Emerging Infections and Biological Threats, Robert Koch Institute, Berlin, Germany.
Karsten SchnatbaumJPT Peptide Technologies GmbH, Berlin, Germany.
Holger WenschuhJPT Peptide Technologies GmbH, Berlin, Germany.
Andreas NitscheHighly Pathogenic Viruses, Centre for Biological Threats and Special Pathogens, WHO Reference Laboratory for SARS-CoV-2 and WHO Collaborating Centre for Emerging Infections and Biological Threats, Robert Koch Institute, Berlin, Germany.
Nils LachmannCharité - Universitätsmedizin Berlin, Institute for Transfusion Medicine, Tissue Typing Laboratory, Berlin, Germany.
Bernd TimmermannMax Planck Institute for Molecular Genetics, Berlin, Germany.
Claudia Giesecke-ThielMax Planck Institute for Molecular Genetics, Berlin, Germany.
Julian BraunSi-M/"Der Simulierte Mensch" a science framework of Technische Universität Berlin and Charité - Universitätsmedizin Berlin, Berlin, Germany.
Florian KernJPT Peptide Technologies GmbH, Berlin, Germany.
Andreas ThielSi-M/"Der Simulierte Mensch" a science framework of Technische Universität Berlin and Charité - Universitätsmedizin Berlin, Berlin, Germany.ORCID 0000-0002-5515-4002

Funding

German Federal Ministry of Education and Research (BMBF)German Federal Ministry of HealthNetwork University Medicine (NUM) 01KX2021
6 · The paper itself

Abstract

Immune evasion by escape mutations subverts immunity against SARS-CoV-2. A role of pan-coronavirus immunity for more durable protection is being discussed, but has remained understudied. We here investigated the effects of age, mutations, and homo-/heterologous vaccination regimens on the dominant pan-coronavirus-specific cellular and humoral epitope iCope after SARS-CoV-2 infection and vaccination in detail. In older individuals, the quantitatively and qualitatively reduced iCope-reactive CD4

Indexed as

AgingCOVID-19Epitopes, T-LymphocyteSARS-CoV-2AdultAgedAntibodies, ViralCD4-Positive T-LymphocytesCOVID-19 VaccinesFemaleHumansImmune EvasionImmunity, HumoralMaleMiddle AgedMutationAntibodies, ViralCOVID-19 VaccinesEpitopes, T-LymphocyteSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2agingcross reactivitypan‐coronavirusSARS‐CoV‐2T cells

Identifiers

PMID40726062
PMCPMC12304627

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.