Evidence map›Paper›PMID 40725765›Full record

ReviewJournal of clinical medicine2025

Hemostasis Laboratory Diagnostics in Newborns.

Chiara Gorio, Angelo Claudio Molinari, Tiziano Martini, Antonietta Ferretti, Giulia Albrici, Giulia Carracchia, Antonella Ierardi, Marzia Leotta, Nicola Portesi, Monica Sacco and 4 more

Abstract readReview
In one paragraph

Review in Journal of clinical medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Chiara GorioPediatric Onco-Hematology Unit, Children's Hospital, ASST Spedali Civili di Brescia, 25123 Brescia, Italy.
Angelo Claudio MolinariThrombosis and Hemostasis Unit, IRCCS Istituto Giannina Gaslini Children's Hospital, 16147 Genoa, Italy.ORCID 0000-0002-8078-8402
Tiziano MartiniRegional Reference Centre for Inherited Bleeding and Thrombotic Disorders, Transfusion Medicine-Città della Salute e della Scienza University Hospital, 10126 Turin, Italy.ORCID 0000-0003-3572-460X
Antonietta FerrettiCenter for Hemorrhagic and Thrombotic Diseases, Foundation University Hospital "A. Gemelli" IRCCS, 00136 Rome, Italy.
Giulia AlbriciPediatric Onco-Hematology Unit, Children's Hospital, ASST Spedali Civili di Brescia, 25123 Brescia, Italy.
Giulia CarracchiaPediatric Onco-Hematology Unit, Children's Hospital, ASST Spedali Civili di Brescia, 25123 Brescia, Italy.
Antonella IerardiHemostasis and Thrombosis Unit, Azienda Ospedaliero Universitaria Renato Dulbecco, 88100 Catanzaro, Italy.ORCID 0000-0001-8508-1636
Marzia LeottaHemostasis and Thrombosis Unit, Azienda Ospedaliero Universitaria Renato Dulbecco, 88100 Catanzaro, Italy.ORCID 0000-0001-8466-6384
Nicola PortesiClinical Chemistry Laboratory, Diagnostic Department, ASST Spedali Civili di Brescia, 25123 Brescia, Italy.
Monica SaccoCenter for Hemorrhagic and Thrombotic Diseases, Foundation University Hospital "A. Gemelli" IRCCS, 00136 Rome, Italy.ORCID 0000-0002-2395-2691
Alessandra StrangioHemostasis and Thrombosis Unit, Azienda Ospedaliero Universitaria Renato Dulbecco, 88100 Catanzaro, Italy.
Maria Elisa MancusoCenter for Thrombosis and Hemorrhagic Diseases, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, Italy.ORCID 0000-0002-7113-4028
Rita Carlotta SantoroHemostasis and Thrombosis Unit, Azienda Ospedaliero Universitaria Renato Dulbecco, 88100 Catanzaro, Italy.ORCID 0000-0002-5081-8201
AICE (Associazione Italiana Centri Emofilia)

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The hemostatic system in the newborn is a complex entity, characterized by dynamism in its development; therefore, the correct measurement of its potential is challenging. In this narrative review, we analyzed the current knowledge of the "developmental hemostasis" of the newborn; we also studied the performance of routine coagulation tests in its evaluation, with considerations about the establishment of neonatal age-specific normal ranges and about the role of preanalytical variables, in particular, hematocrit (which could represent an important cause of error); we also focused on the increasing importance of viscoelastic coagulation tests, which are becoming increasingly widespread (especially in some settings such as intensive care unit) and are able to quickly provide information about the hemostatic function of the newborn, even if they lack adequate standardization in the neonatal period.

Indexed as

bleeding disorderscoagulation testsdevelopmental hemostasishemostasisnewbornviscoelastic tests

Identifiers

PMID40725765
PMCPMC12295540

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.