Evidence map›Paper›PMID 40725503›Full record

ReviewGenes2025

Advances in Precision Therapeutics and Gene Therapy Applications for Retinal Diseases: Impact and Future Directions.

Mariam M AlEissa, Abrar A Alhawsawi, Raghad Alonazi, Enas Magharbil, Abeer Aljahdali, Hani B AlBalawi, Naif M Alali, Syed Hameed, Khaled K Abu-Amero, Moustafa S Magliyah

Abstract readReview
In one paragraph

Review in Genes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Surgical Approaches to Retinal Gene Therapy: 2025 Update.Bioengineering (Basel, Switzerland) · 2025
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mariam M AlEissaResearch Department, King Khaled Eye Specialist Hospital, Riyadh 11462, Saudi Arabia.ORCID 0000-0002-2355-4036
Abrar A AlhawsawiDivision of Ophthalmology, Department of Surgery, College of Medicine, University of Jeddah, Jeddah 23218, Saudi Arabia.
Raghad AlonaziCollege of Medicine, Alfaisal University, Riyadh 11533, Saudi Arabia.ORCID 0009-0001-6714-4143
Enas MagharbilRetina and Uveitis Department, Jeddah Eye Hospital, Jeddah 23454, Saudi Arabia.
Abeer AljahdaliOphthalmology Department, King Abdulaziz University, Jeddah 21589, Saudi Arabia.ORCID 0000-0003-0664-554X
Hani B AlBalawiDivision of Ophthalmology, Department of Surgery, Faculty of Medicine, University of Tabuk, Tabuk 47311, Saudi Arabia.
Naif M AlaliDivision of Ophthalmology, Department of Surgery, Faculty of Medicine, University of Tabuk, Tabuk 47311, Saudi Arabia.ORCID 0009-0008-8860-543X
Syed HameedResearch Department, King Khaled Eye Specialist Hospital, Riyadh 11462, Saudi Arabia.ORCID 0009-0004-2746-0784
Khaled K Abu-AmeroResearch Department, King Khaled Eye Specialist Hospital, Riyadh 11462, Saudi Arabia.
Moustafa S MagliyahResearch Department, King Khaled Eye Specialist Hospital, Riyadh 11462, Saudi Arabia.

Funding

Internal funding from the Research Department, King Khaled Eye Specialist Hospital, Riyadh and the Department of Surgery, Faculty of Medicine, University of Tabuk, Tabuk supported this work. N/A
6 · The paper itself

Abstract

Gene therapy has emerged as a promising treatment for several eye diseases since it may restore vision and stop blindness. Many eye diseases, including retinitis pigmentosa and macular degeneration, have historically been rather difficult to treat and usually cause permanent vision loss. However, thanks to advances in gene therapy, many disorders can now be effectively targeted and genetically changed, providing a safer, more direct, maybe even curative approach. By introducing, altering, or repairing specific genes inside the eye, gene therapy seeks to fix the defective genes causing these disorders, thereby improving general eye health and visual ability. Voretigene neparvovec is one FDA- and EMA-approved treatment for

Indexed as

Genetic TherapyPrecision MedicineRetinal Diseasescis-trans-IsomerasesHumansMacular DegenerationRetinoid Isomerohydrolasecis-trans-IsomerasesRetinoid Isomerohydrolaseeyesgene editinggene therapyretinatherapeutics

Identifiers

PMID40725503
PMCPMC12294471

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.