Evidence map›Paper›PMID 40725496›Full record

ArticleGenes2025

Transcriptomic Profiling Reveals Gene Expression Changes in Mouse Liver Tissue During Alveolar Echinococcosis.

Xiongying Zhang, Qing Zhang, Na Liu, Jia Liu, Huixia Cai, Cunzhe Zhao, Kemei Shi, Wen Lei, Wanli Ma, Shuai Guo and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Xiongying ZhangDepartment of Laboratory Medicine, School of Medicine, Jiangsu University, 301 Xuefu Road, Zhenjiang 212013, China.
Qing ZhangQinghai Institute of Endemic Disease Prevention and Control, Xining 811602, China.
Na LiuQinghai Institute of Endemic Disease Prevention and Control, Xining 811602, China.
Jia LiuQinghai Institute of Endemic Disease Prevention and Control, Xining 811602, China.
Huixia CaiQinghai Institute of Endemic Disease Prevention and Control, Xining 811602, China.
Cunzhe ZhaoQinghai Institute of Endemic Disease Prevention and Control, Xining 811602, China.
Kemei ShiQinghai Institute of Endemic Disease Prevention and Control, Xining 811602, China.
Wen LeiQinghai Institute of Endemic Disease Prevention and Control, Xining 811602, China.
Wanli MaQinghai Institute of Endemic Disease Prevention and Control, Xining 811602, China.
Shuai GuoQinghai Institute of Endemic Disease Prevention and Control, Xining 811602, China.
Wei WangQinghai Institute of Endemic Disease Prevention and Control, Xining 811602, China.
Xiao MaQinghai Institute of Endemic Disease Prevention and Control, Xining 811602, China.
Mei WangDepartment of Laboratory Medicine, School of Medicine, Jiangsu University, 301 Xuefu Road, Zhenjiang 212013, China.ORCID 0000-0003-4483-7286

Funding

Guiding Program Project of the Qinghai Provincial Health and Health System 2022wjzdx-35;The public health service capacity for the prevention and control of major infectious diseases in Qinghai Province has been enhanced 2023-QY-202
6 · The paper itself

Abstract

BACKGROUND/

objectivesAlveolar echinococcosis (AE), caused by

methodsWe established a mouse model of AE by intraperitoneally injecting protoscoleces of

resultsA total of 629 differentially expressed genes (DEGs) were identified. Among them, 370 genes were upregulated and 259 genes were downregulated. Moreover, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses indicated that these DEGs were significantly associated with immune system modulation, the cell cycle, and the fibrosis process during the pathological changes. Additionally, weighted gene co-expression network analysis (WGCNA) identified several genes, including

conclusionsThe findings of this research provide a theoretical foundation for a more in-depth understanding of the molecular mechanisms of AE. They offer valuable insights into the molecular mechanisms and potential key factors involved in the pathogenesis of this disease.

Indexed as

EchinococcosisEchinococcosis, HepaticLiverTranscriptomeAnimalsDisease Models, AnimalEchinococcus multilocularisGene Expression ProfilingGene Expression RegulationMicealveolar echinococcosisdifferentially expressed genes (DEGs)liver tissuesmouse modelRNA sequencing

Identifiers

PMID40725496
PMCPMC12294577

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.