Evidence map›Paper›PMID 40725387›Full record

ArticleGenes2025

AQP7-Mediated Mitochondrial Redox Homeostasis in Vitrified Oocytes: A Genetic Mechanism of PI3K/AKT Signaling Regulation.

Yatian Qi, Wei Xia, Chenyu Tao, Xiaohuan Fang, Yang Yu, Jingwei Hu, Xiaofeng Tian, Tianmiao Qin, Congcong Yao, Wentao Zhang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yatian QiCollege of Animal Science and Technology, Hebei Agricultural University, Baoding 071001, China.
Wei XiaCollege of Animal Science and Technology, Hebei Agricultural University, Baoding 071001, China.ORCID 0000-0001-6835-0320
Chenyu TaoCollege of Animal Science and Technology, Hebei Agricultural University, Baoding 071001, China.
Xiaohuan FangCollege of Animal Science and Technology, Hebei Agricultural University, Baoding 071001, China.
Yang YuCollege of Animal Science and Technology, Hebei Agricultural University, Baoding 071001, China.
Jingwei HuCollege of Animal Science and Technology, Hebei Agricultural University, Baoding 071001, China.
Xiaofeng TianCollege of Animal Science and Technology, Hebei Agricultural University, Baoding 071001, China.
Tianmiao QinCollege of Animal Science and Technology, Hebei Agricultural University, Baoding 071001, China.
Congcong YaoCollege of Animal Science and Technology, Hebei Agricultural University, Baoding 071001, China.
Wentao ZhangCollege of Animal Science and Technology, Hebei Agricultural University, Baoding 071001, China.
Junjie LiCollege of Animal Science and Technology, Hebei Agricultural University, Baoding 071001, China.

Funding

National Key R&D Program of China 2021YFD1200401
6 · The paper itself

Abstract

BACKGROUND/

objectivesCellular oxidative stress is crucial for GV stage oocyte vitrification quality. PI3K and the aquaporin family have been shown to facilitate various cellular processes related to redox homeostasis and energy balance; yet, the mechanisms underlying the involvement of aquaporin 7 (AQP7) in vitrified oocyte oxidative stress remain unclear. The purpose of the present investigation was to evaluate the role of AQP7 in vitrified oocytes and the mechanisms involved.

methodsAQP7 inhibitors were employed to investigate the effect of AQP7 on oxidative stress in mouse-vitrified oocytes, whereas PI3K activators were harnessed to ascertain whether AQP7 serves as a functional molecule involved in this process.

resultsOur results indicate that AQP7 inhibition in vitrified oocytes results in a significant decrease in glutathione (GSH) levels associated with cellular oxidation and an elevation in H

conclusionsOur results provide new insights indicating that PI3K/AKT/AQP7 decreases oxidative stress by regulating mitochondrial morphology, function, and distribution, thereby rescuing oocyte maturation in vitrification.

Indexed as

AquaporinsMitochondriaOocytesPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktAnimalsApoptosisFemaleGlutathioneHomeostasisMiceOxidation-ReductionOxidative StressSignal TransductionVitrificationAqp7 protein, mouseAquaporinsGlutathionePhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktAQP7genetic regulationmitochondriaoocyte cryopreservationPI3K/AKT signalingvitrification

Identifiers

PMID40725387
PMCPMC12294158

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.