ArticleGenes2025
Integrated Transcriptome and Metabolome Analysis of the Porcine Small Intestine During Weaning.
Article in Genes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesIntestinal dysfunction during weaning in piglets causes declines in growth through hindered absorption capacity and intestinal barrier function, equating to economic losses for the porcine industry. Established strategies for mitigating these negative issues are currently lacking.
methodsWe evaluated biomolecular alterations induced by weaning stress through gene expression profiling and metabolome analysis using intestinal samples collected from piglets before weaning, 1 week after weaning, and 2 weeks after weaning.
resultsWe identified 701 differentially expressed genes related to weaning stress, representing the enrichment of Gene Ontology and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways associated with immune response; inflammatory response; cell proliferation; cell adhesion; and carbohydrate, lipid, and calcium ion binding. In the metabolome analysis, ABC transporter; purine, pyrimidine, and Gly-Ser-Thr metabolisms; and the urea cycle were clustered as enriched KEGG pathways. Our results suggest that energy metabolism, including protein metabolism, is involved in the repair of the structural damage occurring in the intestine during weaning.
conclusionsThis study highlights the importance of integrated analyses synthesizing molecular and metabolic mechanisms in elucidating complex biological responses and provides insights into markers that can be used to develop strategies for mitigating weaning stress in the porcine industry.
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