Evidence map›Paper›PMID 40725249›Full record

ArticleInternational journal of molecular sciences2025

Identification of Molecular Subtypes of B-Cell Acute Lymphoblastic Leukemia in Mexican Children by Whole-Transcriptome Analysis.

Norberto Sánchez-Escobar, María de Los Ángeles Romero-Tlalolini, Haydeé Rosas-Vargas, Elva Jiménez-Hernández, Juan Carlos Núñez Enríquez, Angélica Rangel-López, José Manuel Sánchez López, Daniela Rojo-Serrato, América Mariana Jasso Mata, Efraín Abimael Márquez Aguilar and 9 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Norberto Sánchez-EscobarSECIHTI-Facultad de Medicina y Cirugía-Universidad Autónoma "Benito Juárez" de Oaxaca, Mexico City 68020, Mexico.ORCID 0000-0002-1030-5938
María de Los Ángeles Romero-TlaloliniSECIHTI-Facultad de Medicina y Cirugía-Universidad Autónoma "Benito Juárez" de Oaxaca, Mexico City 68020, Mexico.
Haydeé Rosas-VargasUnidad de Investigación Médica en Genética Humana, Hospital de Pediatría "Dr. Silvestre Frenk Freund", Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City 06720, Mexico.ORCID 0000-0003-0635-8284
Elva Jiménez-HernándezServicio de Oncohematología Pediátrica, Hospital Pediátrico Moctezuma, Secretaría de Salud de la Ciudad de México, Mexico City 15530, Mexico.
Juan Carlos Núñez EnríquezDivisión de Investigación en Salud, Hospital de Pediatría "Dr. Silvestre Frenk Freund", Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City 06720, Mexico.ORCID 0000-0002-8070-9727
Angélica Rangel-LópezLaboratorio de Virología Clínica y Experimental, Unidad de Investigación en Enfermedades Infecciosas, Hospital Infantil de México Federico Gómez, Secretaría de Salud, Mexico City 06720, Mexico.ORCID 0000-0001-7040-9379
José Manuel Sánchez LópezUnidad de Investigación Médica en Genética Humana, Hospital de Pediatría "Dr. Silvestre Frenk Freund", Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City 06720, Mexico.ORCID 0000-0002-1349-4746
Daniela Rojo-SerratoUnidad de Investigación Médica en Genética Humana, Hospital de Pediatría "Dr. Silvestre Frenk Freund", Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City 06720, Mexico.
América Mariana Jasso MataUnidad de Investigación Médica en Genética Humana, Hospital de Pediatría "Dr. Silvestre Frenk Freund", Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City 06720, Mexico.
Efraín Abimael Márquez AguilarUnidad de Investigación Médica en Genética Humana, Hospital de Pediatría "Dr. Silvestre Frenk Freund", Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City 06720, Mexico.
Janet Flores-LujanoUnidad de Investigación Médica en Epidemiología Clínica, Hospital de Pediatría "Dr. Silvestre Frenk Freund", Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City 06720, Mexico.
Juan Carlos Bravata-AlcántaraLaboratorio de Genética y Diagnóstico Molecular, Hospital Juárez de México, Mexico City 07760, Mexico.ORCID 0000-0002-3585-0051
Jorge Alfonso Martín-TrejoServicio de Hematología, Hospital de Pediatría "Dr. Silvestre Frenk Freund", Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City 06720, Mexico.
Silvia Jiménez-MoralesLaboratorio de Innovación y Medicina de Precisión, Núcleo "A", Instituto Nacional de Medicina Genómica, Mexico City 14610, Mexico.ORCID 0000-0002-6590-9712
José Arellano-GalindoLaboratorio de Virología Clínica y Experimental, Unidad de Investigación en Enfermedades Infecciosas, Hospital Infantil de México Federico Gómez, Secretaría de Salud, Mexico City 06720, Mexico.ORCID 0000-0001-7289-0821
Aurora Medina SansonDepartamento de Oncología, Hospital Infantil de México Federico Gómez, Secretaría de Salud, Mexico City 06720, Mexico.
Jose Gabriel Peñaloza GonzalezServicio de Onco-Pediatría, Hospital Juárez de México, Secretaría de Salud, Mexico City 07760, Mexico.
Juan Manuel Mejía-AranguréLaboratorio de Genómica Funcional del Cáncer, Instituto Nacional de Medicina Genómica, Mexico City 14610, Mexico.ORCID 0000-0001-8027-6231
Minerva Mata-RochaUnidad de Investigación Médica en Genética Humana, Hospital de Pediatría "Dr. Silvestre Frenk Freund", Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City 06720, Mexico.ORCID 0000-0003-0949-461X

Funding

Support For Infrastructure of Childhood Leukemia Environmental ResearchU24ES028524 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI METAYER, CATHERINE · 2023 to 2025
$1.1M
NIEHS NIH HHS U24 ES028524
6 · The paper itself

Abstract

B-lineage acute lymphoblastic leukemia (B-ALL) is classified into more than 20 molecular subtypes, and next-generation sequencing has facilitated the identification of these with high sensitivity. Bulk RNA-seq analysis of bone marrow was realized to identify molecular subtypes in Mexican pediatric patients with B-ALL. High hyperdiploidy (27.3%) was the most frequent molecular subtype, followed by

Indexed as

Gene Expression ProfilingPrecursor B-Cell Lymphoblastic Leukemia-LymphomaTranscriptomeAdolescentChildChild, PreschoolFemaleHumansInfantMaleMexicoMutationDUX4molecular subtypes of B-ALLNGSRNA-seqtranscriptome

Identifiers

PMID40725249
PMCPMC12295331

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.