New Advances in Small Molecules Targeted at Viral Capsid-Genome Binding.

Jiamei Li, Chengfeng Zhang, Benteng Li, Yuqing Wu

Abstract readReview

In one paragraph

Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jiamei LiState Key Laboratory for Supramolecular Structure and Materials, College of Chemistry, Jilin University, No. 2699 Qianjin Street, Changchun 130012, China.

Chengfeng ZhangState Key Laboratory for Supramolecular Structure and Materials, College of Chemistry, Jilin University, No. 2699 Qianjin Street, Changchun 130012, China.

Benteng LiState Key Laboratory for Supramolecular Structure and Materials, College of Chemistry, Jilin University, No. 2699 Qianjin Street, Changchun 130012, China.

Yuqing WuState Key Laboratory for Supramolecular Structure and Materials, College of Chemistry, Jilin University, No. 2699 Qianjin Street, Changchun 130012, China.ORCID 0000-0003-4883-5982

Funding

project of NSFC No. 21875085the Innovation & Opening Program of the State Key Laboratory of Supramolecular Structure and Materials, Jilin University Nothe Jilin Province Science and Technology Development Plan Project No. 20230204040YY

6 · The paper itself

Abstract

The capsid protein plays a crucial role in the viral life cycle. By interacting with the viral genome, it facilitates the assembly of the nucleocapsid, ultimately leading to the formation of the viral particle. Therefore, interfering with or disrupting the interaction between the capsid protein and viral genome can effectively inhibit viral replication and infection. This review focuses on elucidating the binding mechanisms between the capsid protein and the viral genome, as well as their potential applications as therapeutic targets. In particular, it summarizes the research progress on small-molecule drugs targeting the capsid-genome binding sites of dengue virus, HBV, and SARS-CoV-2. Notably, this review provides a detailed discussion on the mechanisms by which these small-molecule inhibitors interfere with the capsid-genome interaction, aiming to offer inspiration for the future development of novel antiviral drugs targeting the capsid-genome binding.

Indexed as

Antiviral AgentsCapsidCapsid ProteinsGenome, ViralSmall Molecule LibrariesAnimalsBinding SitesCOVID-19 Drug TreatmentDengue VirusHepatitis B virusHumansProtein BindingSARS-CoV-2Virus ReplicationAntiviral AgentsCapsid ProteinsSmall Molecule Librariesantiviral strategycapsid–genome bindingcapsid protein (Cp)small moleculeviral inhibitor

Identifiers

PMID40725228

DOI10.3390/ijms26146979

PMCPMC12295584

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.