Evidence map›Paper›PMID 40725212›Full record

ArticleInternational journal of molecular sciences2025

Genetic Correlates of Presenile Dementia and Cognitive Decline in the Armenian Population Following COVID-19: A Case-Control Study.

Yekaterina Hovhannisyan, Hermine Yeritsyan, Gohar Hakobjanyan, Gayane Petrosyan, Hayk Harutyunyan, Armen Muradyan, Allen Azizian, Konstantin Yenkoyan

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PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yekaterina HovhannisyanNeuroscience Laboratory, COBRAIN Center, Yerevan State Medical University Named after Mkhitar Heratsi, Yerevan 0025, Armenia.
Hermine YeritsyanNeuroscience Laboratory, COBRAIN Center, Yerevan State Medical University Named after Mkhitar Heratsi, Yerevan 0025, Armenia.
Gohar HakobjanyanLaboratory-Diagnostic Center Heratsi N1 University Clinic, Yerevan State Medical University Named after Mkhitar Heratsi, Yerevan 0025, Armenia.
Gayane PetrosyanLaboratory-Diagnostic Center Heratsi N1 University Clinic, Yerevan State Medical University Named after Mkhitar Heratsi, Yerevan 0025, Armenia.
Hayk HarutyunyanNeuroscience Laboratory, COBRAIN Center, Yerevan State Medical University Named after Mkhitar Heratsi, Yerevan 0025, Armenia.ORCID 0000-0001-5674-5130
Armen MuradyanCOBRAIN Center, Yerevan State Medical University Named after Mkhitar Heratsi, Yerevan 0025, Armenia.
Allen AzizianDepartment of Criminology, California State University, Fresno, CA 93740, USA.
Konstantin YenkoyanNeuroscience Laboratory, COBRAIN Center, Yerevan State Medical University Named after Mkhitar Heratsi, Yerevan 0025, Armenia.ORCID 0000-0003-3346-4306

Funding

State Committee of Science 25YSMU-CON-I-3A
6 · The paper itself

Abstract

The presence of cognitive lapses in the post-COVID-19 period, particularly among younger individuals, suggests a potential genetic predisposition. This case-control study aimed to assess the association between neurodegeneration-associated genes and cognitive declines in the post-COVID-19 Armenian population under the age of 65. In addition, we examined other contributing factors, including depressive symptoms, hypovitaminosis D, vitamin B12 and B9 deficiencies, and some viral infections, as potential confounders or effect modifiers. A total of 162 participants (ages 19-65, Med = 43), who were exposed to SARS-CoV-2 in Armenia between 2020 and 2022, participated in this study. Standardized assessments, including the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and the Montreal Cognitive Assessment (MoCA), were used to evaluate cognitive functions and mental status, while the Patient Health Questionnaire-9 (PHQ-9) was utilized to assess depressive symptoms. Clinical interview data, comprising yes/no self-reports regarding the presence of cognitive problems and depressive symptoms, were also included. Genetic analysis identified copy number variations (CNVs) in the

Indexed as

Alzheimer DiseaseCognitive DysfunctionCOVID-19AdultAgedArmeniaCase-Control StudiesFemaleGenetic Predisposition to DiseaseHumansMaleMiddle AgedSARS-CoV-2Young AdultcognitionCOVID-19dementiadepressionenvironmentgene

Identifiers

PMID40725212
PMCPMC12295909

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.