Evidence map›Paper›PMID 40725207›Full record

ArticleInternational journal of molecular sciences2025

CALB Immobilized on Octyl-Agarose-An Efficient Pharmaceutical Biocatalyst for Transesterification in Organic Medium.

Joanna Siódmiak, Jacek Dulęba, Natalia Kocot, Rafał Mastalerz, Gudmundur G Haraldsson, Tomasz Siódmiak

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Joanna SiódmiakDepartment of Laboratory Medicine, Faculty of Pharmacy, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, 85-094 Bydgoszcz, Poland.
Jacek DulębaDepartment of Pharmacy Practice, Faculty of Pharmacy, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, 85-089 Bydgoszcz, Poland.
Natalia KocotDoctoral School of Medical and Health Sciences, Jagiellonian University, 31-530 Kraków, Poland.ORCID 0000-0001-9107-263X
Rafał MastalerzDepartment of Medicinal Chemistry, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, 85-089 Bydgoszcz, Poland.ORCID 0000-0002-8111-8945
Gudmundur G HaraldssonScience Institute, University of Iceland, 107 Reykjavik, Iceland.ORCID 0000-0002-5664-2745
Tomasz SiódmiakDepartment of Pharmacy Practice, Faculty of Pharmacy, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, 85-089 Bydgoszcz, Poland.ORCID 0000-0002-9232-5798

Funding

Excellence Initiative - Debuts, under the "Excellence Initiative-Research University" program, NCU in Toruń 9/2022/Debiuty3 and 6/2022/Debiuty3
6 · The paper itself

Abstract

The growing need for developing safer and more effective methods for obtaining enantiomers of chiral compounds, particularly those with pharmacological activity, highlights the potential of biocatalysis as an appropriate pharmaceutical research direction. However, low catalytic activity and stability of free enzymes are often among the substantial limitations to the wide application of biocatalysis. Therefore, to overcome these obstacles, new technological procedures are being designed. In this study, we present optimized protocols for the immobilization of

Indexed as

Enzymes, ImmobilizedFungal ProteinsLipaseSepharoseBiocatalysisEnzyme StabilityEsterificationHydrogen-Ion ConcentrationKineticsStereoisomerismTemperatureEnzymes, ImmobilizedFungal ProteinsLipaselipase B, Candida antarcticaSepharoseclimatic chamberenantioselective transesterificationimmobilizationkinetic resolutionlipase B from Candida antarcticaoctyl-agaroseoctyl-Sepharose CL-4B(R,S)-1-phenylethanolstorage stabilitythermal stability

Identifiers

PMID40725207
PMCPMC12295511

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.