Evidence map›Paper›PMID 40725194›Full record

ArticleInternational journal of molecular sciences2025

Mouse PrimPol Outperforms Its Human Counterpart as a Robust DNA Primase.

Gustavo Carvalho, Susana Guerra, María I Martínez-Jiménez, Luis Blanco

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Gustavo CarvalhoCentro de Biología Molecular "Severo Ochoa" (CSIC-UAM), c/Nicolás Cabrera 1, 28049 Madrid, Spain.ORCID 0000-0002-3827-4619
Susana GuerraCentro de Biología Molecular "Severo Ochoa" (CSIC-UAM), c/Nicolás Cabrera 1, 28049 Madrid, Spain.
María I Martínez-JiménezCentro de Biología Molecular "Severo Ochoa" (CSIC-UAM), c/Nicolás Cabrera 1, 28049 Madrid, Spain.ORCID 0000-0002-7653-2877
Luis BlancoCentro de Biología Molecular "Severo Ochoa" (CSIC-UAM), c/Nicolás Cabrera 1, 28049 Madrid, Spain.ORCID 0000-0001-5558-4435

Funding

MINECO BFU2015-65880-PMinisterio de Ciencia, Innovación y Universidades PGC2018-093576-B-C21 ; PID2021-125966OB-I00
6 · The paper itself

Abstract

The human PrimPol counteracts DNA replication stress by repriming DNA synthesis when fork progression is hindered by UV light or hydroxyurea treatment, or by encountering complex DNA structures, such as G-quadruplexes, R-loops, or interstrand crosslinks. The

Indexed as

DNA-Directed DNA PolymeraseDNA PrimaseMultifunctional EnzymesAnimalsDNADNA ReplicationHumansMiceDNADNA-Directed DNA PolymeraseDNA PrimaseMultifunctional EnzymesPrimPol protein, humanDNA primaseDNA replicationmouse PrimPolPrimPol

Identifiers

PMID40725194
PMCPMC12294863

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.