Evidence map›Paper›PMID 40725167›Full record

ArticleInternational journal of molecular sciences2025

Hydrogen Gas Attenuates Toxic Metabolites and Oxidative Stress-Mediated Signaling to Inhibit Neurodegeneration and Enhance Memory in Alzheimer's Disease Models.

Sofian Abdul-Nasir, Cat Tuong Chau, Tien Thuy Nguyen, Johny Bajgai, Md Habibur Rahman, Kwon Hwang-Un, In-Soo You, Cheol-Su Kim, Bo Am Seo, Kyu-Jae Lee

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sofian Abdul-NasirDepartment of Global Medical Science, Wonju College of Medicine, Yonsei University, Wonju 26426, Republic of Korea.ORCID 0009-0007-6680-3075
Cat Tuong ChauDepartment of Global Medical Science, Wonju College of Medicine, Yonsei University, Wonju 26426, Republic of Korea.ORCID 0009-0000-6584-6435
Tien Thuy NguyenDepartment of Global Medical Science, Wonju College of Medicine, Yonsei University, Wonju 26426, Republic of Korea.ORCID 0009-0001-1424-8379
Johny BajgaiDepartment of Convergence Medicine, Wonju College of Medicine, Yonsei University, Wonju 26426, Republic of Korea.ORCID 0000-0002-7228-8053
Md Habibur RahmanDepartment of Convergence Medicine, Wonju College of Medicine, Yonsei University, Wonju 26426, Republic of Korea.
Kwon Hwang-UnGOOTZ Co., Ltd., Yuljeongro, 247 beon-gil, Yangju-si 11457, Republic of Korea.
In-Soo YouGOOTZ Co., Ltd., Yuljeongro, 247 beon-gil, Yangju-si 11457, Republic of Korea.
Cheol-Su KimDepartment of Convergence Medicine, Wonju College of Medicine, Yonsei University, Wonju 26426, Republic of Korea.ORCID 0000-0002-9927-9990
Bo Am SeoDepartment of Global Medical Science, Wonju College of Medicine, Yonsei University, Wonju 26426, Republic of Korea.
Kyu-Jae LeeDepartment of Global Medical Science, Wonju College of Medicine, Yonsei University, Wonju 26426, Republic of Korea.ORCID 0000-0001-8748-8122

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) is a neurodegenerative condition in which amyloid-beta (Aβ) plaques trigger oxidative stress (OS) and neuroinflammation, causing memory loss. OS and neurodegeneration can also be caused by reactive astrocytes, thereby promoting AD via toxic metabolite accumulation in the astrocytic urea cycle. However, the effect of molecular hydrogen (H

Indexed as

Alzheimer DiseaseHydrogenMemoryOxidative StressAmyloid beta-PeptidesAnimalsAstrocytesDisease Models, AnimalHippocampusHydrogen PeroxideMaleMaze LearningMemory DisordersMiceMice, TransgenicSignal TransductionAmyloid beta-PeptidesHydrogenHydrogen PeroxideAlzheimer’s diseaseapoptosisastrocytes and urea cyclemolecular hydrogenneurodegenerationneuroinflammationoxidative stress

Identifiers

PMID40725167
PMCPMC12295766

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.