ArticleInternational journal of molecular sciences2025
Quantitative Proteomics Reveals Fh15 as an Antagonist of TLR4 Downregulating the Activation of NF-κB, Inducible Nitric Oxide, Phagosome Signaling Pathways, and Oxidative Stress of LPS-Stimulated Macrophages.
Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
9 authors.
Albersy Armina-RodriguezDepartment of Microbiology and Medical Zoology, University of Puerto Rico-Medical Sciences Campus, San Juan, PR 00936, USA.ORCID 0000-0002-7126-2804
Bianca N Valdés FernandezDepartment of Microbiology and Medical Zoology, University of Puerto Rico-Medical Sciences Campus, San Juan, PR 00936, USA.
Carlimar Ocasio-MalavéDepartment of Microbiology and Medical Zoology, University of Puerto Rico-Medical Sciences Campus, San Juan, PR 00936, USA.ORCID 0009-0009-7046-1076
Yadira M Cantres RosarioTranslational Proteomics Center, Research Capacity Core, Center for Collaborative Research in Health Disparities (CCRHD), Academic Affairs Deanship, University of Puerto Rico-Medical Sciences Campus, San Juan, PR 00936, USA.
Kelvin Carrasquillo CarriónIntegrated Informatics Services, Research Capacity Core, Center for Collaborative Research in Health Disparities (CCRHD), Academic Affairs Deanship, University of Puerto Rico-Medical Sciences Campus, San Juan, PR 00936, USA.ORCID 0000-0001-7224-2349
Loyda M MeléndezDepartment of Microbiology and Medical Zoology, University of Puerto Rico-Medical Sciences Campus, San Juan, PR 00936, USA.ORCID 0000-0003-2571-8206
Abiel Roche LimaIntegrated Informatics Services, Research Capacity Core, Center for Collaborative Research in Health Disparities (CCRHD), Academic Affairs Deanship, University of Puerto Rico-Medical Sciences Campus, San Juan, PR 00936, USA.ORCID 0000-0003-2246-6744
Eduardo L Tosado RodriguezIntegrated Informatics Services, Research Capacity Core, Center for Collaborative Research in Health Disparities (CCRHD), Academic Affairs Deanship, University of Puerto Rico-Medical Sciences Campus, San Juan, PR 00936, USA.ORCID 0000-0002-9140-8671
Ana M EspinoDepartment of Microbiology and Medical Zoology, University of Puerto Rico-Medical Sciences Campus, San Juan, PR 00936, USA.ORCID 0000-0001-8456-2550
Funding
Targeting professional APCs using Fasciola hepatica FABP to suppresses inflammationSC1AI155439 · NIAID · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI ESPINO, ANA M · 2020 to 2023
$1.5M
National Institute of Allergies and Infectious Diseases 1SC1AI155439-01NIAID NIH HHS SC1 AI155439
6 · The paper itself
Abstract
There is a present need to develop alternative biotherapeutic drugs to mitigate the exacerbated inflammatory immune responses characteristic of sepsis. The potent endotoxin lipopolysaccharide (LPS), a major component of Gram-negative bacterial outer membrane, activates the immune system via Toll-like receptor 4 (TLR4), triggering macrophages and a persistent cascade of inflammatory mediators. Our previous studies have demonstrated that Fh15, a recombinant member of the
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Quantitative Proteomics Reveals Fh15 as an Antagonist of TLR4 Downregulating the Activation of NF-κB, Inducible Nitric Oxide, Phagosome Signaling Pathways, and Oxidative Stress of LPS-Stimulated Macrophages. · full record | OpenQuestion