Evidence map›Paper›PMID 40725152›Full record

ArticleInternational journal of molecular sciences2025

Identification of Genetic Variants Using Next-Generation Sequencing in Pediatric Myelodysplastic Syndrome: From Disease Biology to Clinical Applications.

Viviane Lamim Lovatel, Gerson Moura Ferreira, Beatriz Ferreira da Silva, Rayane de Souza Torres, Rita de Cássia Barbosa da Silva Tavares, Ana Paula Silva Bueno, Eliana Abdelhay, Teresa de Souza Fernandez

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Viviane Lamim LovatelCytogenetic Laboratory, Cell and Gene Therapy Program, Instituto Nacional de Câncer (INCA), Rio de Janeiro 20230-130, RJ, Brazil.ORCID 0000-0001-8493-5855
Gerson Moura FerreiraStem Cell Laboratory, Instituto Nacional de Câncer, Rio de Janeiro 20230-130, RJ, Brazil.ORCID 0000-0002-3467-2580
Beatriz Ferreira da SilvaCytogenetic Laboratory, Cell and Gene Therapy Program, Instituto Nacional de Câncer (INCA), Rio de Janeiro 20230-130, RJ, Brazil.ORCID 0000-0003-4375-9300
Rayane de Souza TorresCytogenetic Laboratory, Cell and Gene Therapy Program, Instituto Nacional de Câncer (INCA), Rio de Janeiro 20230-130, RJ, Brazil.ORCID 0000-0001-9473-7596
Rita de Cássia Barbosa da Silva TavaresBone Marrow Transplantation Center, Instituto Nacional de Câncer (INCA), Rio de Janeiro 20230-130, RJ, Brazil.
Ana Paula Silva BuenoFaculdade de Medicina, Instituto de Pediatria e Puericultura Martagão Gesteira, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-912, RJ, Brazil.
Eliana AbdelhayStem Cell Laboratory, Instituto Nacional de Câncer, Rio de Janeiro 20230-130, RJ, Brazil.ORCID 0000-0001-5166-0832
Teresa de Souza FernandezCytogenetic Laboratory, Cell and Gene Therapy Program, Instituto Nacional de Câncer (INCA), Rio de Janeiro 20230-130, RJ, Brazil.ORCID 0000-0003-1299-4666

Funding

Fundação Carlos Chagas Filho de Amaro à Pesquisa do Estado do Rio de Janeiro (FAPERJ) FAPERJ/E-26/201.2018/2022
6 · The paper itself

Abstract

This study aimed to identify genetic variants using a customized next-generation sequencing (NGS) panel for pediatric myelodysplastic syndrome (pMDS) and to explore their associations with cytogenetic and clinical characteristics. Cytogenetic analyses were conducted using G-banding and fluorescence in situ hybridization. NGS was performed with the Ion Torrent Personal Genome Machine for the following genes:

Indexed as

Genetic VariationHigh-Throughput Nucleotide SequencingMyelodysplastic SyndromesAdolescentChildChild, PreschoolFemaleGenetic Predisposition to DiseaseHumansInfantMaleMutationgenetic variantspediatric myelodysplastic syndrometargeted NGS panel

Identifiers

PMID40725152
PMCPMC12294961

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.