Evidence map›Paper›PMID 40725141›Full record

ReviewInternational journal of molecular sciences2025

Nature-Inspired Strategies in Cancer Management: The Potential of Plant Extracts in Modulating Tumour Biology.

Marcin Hołota, Małgorzata M Posmyk

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Pharmaceutics · 2026
    Article
  3. Article
  4. International journal of molecular sciences · 2026
    Article
  5. Review
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Marcin HołotaDepartment of Plant Ecophysiology, Faculty of Biology and Environmental Protection, University of Lodz, Banacha 12/16, 90-237 Lodz, Poland.ORCID 0000-0003-3783-7093
Małgorzata M PosmykDepartment of Plant Ecophysiology, Faculty of Biology and Environmental Protection, University of Lodz, Banacha 12/16, 90-237 Lodz, Poland.ORCID 0000-0002-3147-6250

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer is a serious group of diseases that is a huge problem on a global scale and is the second most common cause of death. Commonly used therapies do not always lead to the complete elimination of diseased cells or tissues and are also burdened with side effects that reduce the quality of life of patients. Due to these difficulties, new therapeutic approaches are still being sought. In recent years, there has been a return to interest in natural methods of treating various diseases, among which phytochemicals are particularly interesting. This article reviews plant extracts with anticancer properties with different mechanisms of action (proapoptotic, antiproliferative, antiangiogenic, immunomodulatory). In addition, plant extracts that reduce the side effects of chemotherapy and the limitations and prospects for the use of plant extracts in anticancer therapy are described. Our goal was to create an up-to-date information base that would encourage scientists to intensify research into supplementing targeted anticancer therapies with additional protective and preventive measures, in which natural mixtures of phytochemicals (plant extracts) are effective allies. At the same time, we encourage discussion on the limitations of their use in light of the orthodox principles of classical medicine and pharmacy (issues of safety, quality, drug purity, and dose precision), which are a priori correct but have not yet led to the elimination of cancer from the group of incurable diseases.

Indexed as

Antineoplastic Agents, PhytogenicNeoplasmsPlant ExtractsAnimalsHumansPhytochemicalsAntineoplastic Agents, PhytogenicPhytochemicalsPlant Extractsantiangiogenic activityantiproliferative activitycancerimmunomodulatory activityphytochemicalsplant extractsproapoptotic activityrevised hallmarks of cancer

Identifiers

PMID40725141
PMCPMC12294938

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.