Evidence map›Paper›PMID 40725119›Full record

ArticleInternational journal of molecular sciences2025

Characterization of DNA Methylation Episignatures for Radon-Induced Lung Cancer.

Ziyan Yan, Huixi Chen, Yuhao Liu, Lin Zhou, Jiaojiao Zhu, Yifan Hou, Xinyu Zhang, Zhongmin Chen, Yilong Wang, Ping-Kun Zhou and 1 more

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ziyan YanBeijing Institute of Radiation Medicine, Beijing 100850, China.ORCID 0000-0001-8211-6063
Huixi ChenHengyang Medical College, University of South China, Hengyang 421001, China.
Yuhao LiuBeijing Institute of Radiation Medicine, Beijing 100850, China.
Lin ZhouBeijing Institute of Radiation Medicine, Beijing 100850, China.
Jiaojiao ZhuBeijing Institute of Radiation Medicine, Beijing 100850, China.
Yifan HouCollege of Life Sciences, Hebei University, Baoding 071001, China.
Xinyu ZhangSchool of Public Health, University of South China, Hengyang 421001, China.
Zhongmin ChenPLA Rocket Force Characteristic Medical Center, Beijing 100850, China.
Yilong WangBeijing Institute of Radiation Medicine, Beijing 100850, China.
Ping-Kun ZhouBeijing Institute of Radiation Medicine, Beijing 100850, China.ORCID 0000-0001-7666-1209
Yongqing GuBeijing Institute of Radiation Medicine, Beijing 100850, China.

Funding

National Natural Science Foundation of China 82073488National Natural Science Foundation of China 82273568
6 · The paper itself

Abstract

Radon (Rn) exposure has a strong association with lung cancer risk and is influenced by epigenetic modifications. To investigate the characterization of DNA methylation (DNAm) episignatures for radon-induced lung cancer, we detected the specific changes in DNAm in blood and lung tissues using reduced representation bisulfite sequencing (RRBS). We identified the differentially methylated regions (DMRs) induced by radon exposure. The bioinformatics analysis of the DMR-mapped genes revealed that pathways in cancer were affected by radon exposure. Among them, the DNAm episignatures of MAPK10, PLCG1, PLCβ3 and PIK3R2 were repeated between lung tissue and blood, and validated by the MassArray. In addition, radon exposure promoted lung cancer development in the genetic engineering mouse model (GEMM), accompanied by decreased MAPK10 and increased PLCG1, PLCβ3, and PIK3R2 with mRNA and protein levels. Conclusively, radon exposure significantly changes the genomic DNAm patterns in lung tissue and blood. The DNAm episignatures of MAPK10, PLCG1, PLCβ3 and PIK3R2 have a significant influence on radon-induced lung cancer. This brings a new perspective to understanding the pathways involved in radon-induced lung cancer and offers potential targets for developing blood-based biomarkers and epigenetic therapeutics.

Indexed as

DNA MethylationLung NeoplasmsNeoplasms, Radiation-InducedRadonAnimalsEpigenesis, GeneticGene Expression Regulation, NeoplasticHumansMaleMiceRadonDNA methylationepisignatureslung cancerMassArrayradonRRBS

Identifiers

PMID40725119
PMCPMC12295219

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.