Evidence map›Paper›PMID 40725113›Full record

ReviewInternational journal of molecular sciences2025

The First Case Report of a Solitary Pulmonary Metastasis of a Transitional Meningioma and Literature Review.

Sara Di Lorenzo, Stefano Farese, Ciro Balbo, Federica Melisi, Marianna Scrima, Lucia Stefania Pasquale, Maria Pasqualina Laudato, Teresa Peluso, Domenico Solari, Andrea Ronchi and 8 more

Abstract readCase ReportsReview
In one paragraph

Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Sara Di LorenzoMedical Oncology, Department of Precision Medicine, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.ORCID 0009-0007-5205-7788
Stefano FareseMedical Oncology, Department of Precision Medicine, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.
Ciro BalboMedical Oncology, Department of Precision Medicine, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.
Federica MelisiLaboratory of Precision and Molecular Oncology, Biogem Scarl, Institute of Genetic Research, Contrada Camporeale, Ariano Irpino, 83031 Avellino, Italy.ORCID 0000-0002-5957-9876
Marianna ScrimaLaboratory of Precision and Molecular Oncology, Biogem Scarl, Institute of Genetic Research, Contrada Camporeale, Ariano Irpino, 83031 Avellino, Italy.ORCID 0000-0003-4636-7695
Lucia Stefania PasqualeLaboratory of Precision and Molecular Oncology, Biogem Scarl, Institute of Genetic Research, Contrada Camporeale, Ariano Irpino, 83031 Avellino, Italy.
Maria Pasqualina LaudatoMedical Oncology, Department of Precision Medicine, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.
Teresa PelusoLaboratory of Precision and Molecular Oncology, Biogem Scarl, Institute of Genetic Research, Contrada Camporeale, Ariano Irpino, 83031 Avellino, Italy.
Domenico SolariDivision of Neurosurgery, Department of Neurosciences, Reproductive and Odontostomatological Sciences, Federico II University, 80131 Naples, Italy.ORCID 0000-0003-1535-8737
Andrea RonchiPathology Unit, Department of Mental and Physical Health and Preventive Medicine, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.
Marina AccardoPathology Unit, Department of Mental and Physical Health and Preventive Medicine, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.
Renato FrancoPathology Unit, Department of Mental and Physical Health and Preventive Medicine, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.
Raffaele AddeoOncology Unit, Hospital "San Giovanni di Dio" of Frattamaggiore, ASL Napoli 2 Nord, 80027 Frattamaggiore, Italy.ORCID 0000-0001-9197-8060
Teresa SommaDivision of Neurosurgery, Department of Neurosciences, Reproductive and Odontostomatological Sciences, Federico II University, 80131 Naples, Italy.
Mario PirozziSCDU Oncologia, Azienda Ospedaliera Universitaria Maggiore della Carità, 28100 Novara, Italy.
Fortunato CiardielloMedical Oncology, Department of Precision Medicine, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.
Michele CaragliaLaboratory of Precision and Molecular Oncology, Biogem Scarl, Institute of Genetic Research, Contrada Camporeale, Ariano Irpino, 83031 Avellino, Italy.ORCID 0000-0003-2408-6091
Morena FasanoMedical Oncology, Department of Precision Medicine, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.ORCID 0000-0003-0782-8778

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extracranial metastases from meningiomas are extremely rare, with an incidence of <1%, and their prognosis is poor. Moreover, there is currently no gold standard for their treatment; therefore, the decision-making process is strictly dependent on multidisciplinary discussions. In this report, we describe the case of a 73-year-old patient who was diagnosed with a solitary lung metastasis more than 20 years after the initial treatment for a low-grade meningioma. Molecular characterization of this metastasis was performed using the Oncomine Comprehensive Assay Plus, which identified multiple functional mutations in the beta2-microglobulin (β2M) and ATM genes, both of which may contribute to immune evasion and genomic instability. A short overview of the literature is also reported. To our knowledge, no previous reports exist on single pulmonary metastasis from low-grade meningioma occurring more than 20 years after diagnosis.

Indexed as

Lung NeoplasmsMeningeal NeoplasmsMeningiomaAgedAtaxia Telangiectasia Mutated Proteinsbeta 2-MicroglobulinHumansMutationAtaxia Telangiectasia Mutated ProteinsATM protein, humanbeta 2-MicroglobulinAtaxia–Telangiectasia Mutatedbeta2-microglobulinlung metastasistransitional meningioma

Identifiers

PMID40725113
PMCPMC12295162

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.