Evidence map›Paper›PMID 40725109›Full record

ArticleInternational journal of molecular sciences2025

Do NGF and LPS Interact Synergistically to Modulate Inflammation in Sheep Endometrial Epithelial Cells?

Gabriella Guelfi, Camilla Capaccia, Vicente Francisco Ratto, Cecilia Dall'Aglio, Francesca Mercati, Margherita Maranesi

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Gabriella GuelfiDepartment of Veterinary Medicine, University of Perugia, Via San Costanzo 4, 06126 Perugia, Italy.ORCID 0000-0003-3695-9275
Camilla CapacciaDepartment of Veterinary Medicine, University of Perugia, Via San Costanzo 4, 06126 Perugia, Italy.ORCID 0000-0002-1040-6245
Vicente Francisco RattoDepartment of Veterinary Medicine, University of Perugia, Via San Costanzo 4, 06126 Perugia, Italy.
Cecilia Dall'AglioDepartment of Veterinary Medicine, University of Perugia, Via San Costanzo 4, 06126 Perugia, Italy.ORCID 0000-0001-6451-3751
Francesca MercatiDepartment of Veterinary Medicine, University of Perugia, Via San Costanzo 4, 06126 Perugia, Italy.ORCID 0000-0002-8799-1200
Margherita MaranesiDepartment of Veterinary Medicine, University of Perugia, Via San Costanzo 4, 06126 Perugia, Italy.ORCID 0000-0002-1727-4118

Funding

Prof. Margherita Maranesi by the University of Perugia, Italy, "Basic Research Fund 2021" (Title: "Ovulation induction factors in sheep: their role in estrus seasonality and related inflammatory mechanisms"), and by a grant assigned to Prof. Cecilia Dall' Basic Research Fund 2021, and Fondazione Cassa Risparmio cod. 2022.0395
6 · The paper itself

Abstract

Neurotrophins and inflammatory mediators are known to influence endometrial function, but their interplay in luminal epithelial cells remains poorly characterized. In this study, sheep endometrial luminal epithelial cells (SELECs) were treated with nerve growth factor (NGF), lipopolysaccharide (LPS), or both, and the effects on gene expression and prostaglandin secretion were evaluated. NGF stimulation alone induced a clear transcriptional activation of

Indexed as

EndometriumEpithelial CellsInflammationLipopolysaccharidesNerve Growth FactorAnimalsCyclooxygenase 2DinoprostoneFemaleGene Expression RegulationProstaglandinsReceptor, trkASheepCyclooxygenase 2DinoprostoneLipopolysaccharidesNerve Growth FactorProstaglandinsReceptor, trkAendometrial epithelial cellsnerve growth factorneuroimmune regulationprostaglandin biosynthesisTLR4 signaling

Identifiers

PMID40725109
PMCPMC12295654

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.