Evidence map›Paper›PMID 40725095›Full record

ArticleInternational journal of molecular sciences2025

Genetic Landscape of a Pleural Mesothelioma in a Child Affected by NF2-Related Schwannomatosis.

Marzia Ognibene, Gianluca Piccolo, Marco Crocco, Marco Di Duca, Antonio Verrico, Marta Molteni, Ferruccio Romano, Valeria Capra, Andrea Rossi, Federico Zara and 2 more

Abstract readCase Reports
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Marzia OgnibeneU.O.C. Genetica Medica, IRCCS Istituto Giannina Gaslini, 16147 Genova, Italy.ORCID 0000-0003-3698-9319
Gianluca PiccoloU.O.S.D. Neuro Oncologia, IRCCS Istituto Giannina Gaslini, 16147 Genova, Italy.
Marco CroccoU.O.C. Gastroenterologia Pediatrica, IRCCS Istituto Giannina Gaslini, 16147 Genova, Italy.ORCID 0000-0001-7277-4767
Marco Di DucaU.O.C. Genetica Medica, IRCCS Istituto Giannina Gaslini, 16147 Genova, Italy.
Antonio VerricoU.O.S.D. Neuro Oncologia, IRCCS Istituto Giannina Gaslini, 16147 Genova, Italy.ORCID 0000-0002-4648-4384
Marta MolteniU.O.S.D. Neuro Oncologia, IRCCS Istituto Giannina Gaslini, 16147 Genova, Italy.
Ferruccio RomanoU.O.C. Genetica Clinica, IRCCS Istituto Giannina Gaslini, 16147 Genova, Italy.
Valeria CapraU.O.C. Genetica Clinica, IRCCS Istituto Giannina Gaslini, 16147 Genova, Italy.ORCID 0000-0002-3097-0388
Andrea RossiU.O.C. Neuroradiologia, IRCCS Istituto Giannina Gaslini, 16147 Genova, Italy.
Federico ZaraU.O.C. Genetica Medica, IRCCS Istituto Giannina Gaslini, 16147 Genova, Italy.ORCID 0000-0001-9744-5222
Patrizia De MarcoU.O.C. Genetica Medica, IRCCS Istituto Giannina Gaslini, 16147 Genova, Italy.ORCID 0000-0001-8498-3750
Claudia MilanaccioU.O.S.D. Neuro Oncologia, IRCCS Istituto Giannina Gaslini, 16147 Genova, Italy.

Funding

Italian Ministry of Health, RICERCA CORRENTE 2024 MSALRC24
6 · The paper itself

Abstract

We report the first case of pleural mesothelioma (PM) occurring in a child affected by NF2-related schwannomatosis (NF2-SWN) and without any history of environmental exposure to asbestos. Mesothelioma is a rare secondary tumor in brain cancer patients and the association with NF2-SWN has been described only in a few anecdotal cases and never in the pediatric field. NF2-SWN is an autosomal dominant disease caused by inactivating germline mutations of the

Indexed as

MesotheliomaNeurilemmomaNeurofibromatosesNeurofibromatosis 2Neurofibromin 2Pleural NeoplasmsSkin NeoplasmsHumansInfantMaleMesothelioma, MalignantNeurofibromin 2NF2 protein, humancancer-related geneschromosomal aberrationsneurofibromatosis type 2NF2-related schwannomatosispediatric pleural mesothelioma

Identifiers

PMID40725095
PMCPMC12295179

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.