Evidence map›Paper›PMID 40725049›Full record

ArticleInternational journal of molecular sciences2025

Regeneration of Biomechanically Functional Tendon Tissue Following Injection of Uncultured, Autologous, Adipose-Derived Regenerative Cells into Partial Achilles Tendon Defects in Rabbits.

Christoph Schmitz, Christopher Alt, Tobias Wuerfel, Stefan Milz, Jacqueline Dinzey, Ashley Hill, Katie J Sikes, Lindsey H Burton, Jeremiah Easley, Holly L Stewart and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Christoph SchmitzInstitute of Anatomy, Faculty of Medicine, LMU Munich, 80331 Munich, Germany.
Christopher AltInstitute of Anatomy, Faculty of Medicine, LMU Munich, 80331 Munich, Germany.
Tobias WuerfelInstitute of Anatomy, Faculty of Medicine, LMU Munich, 80331 Munich, Germany.ORCID 0000-0001-9353-8501
Stefan MilzInstitute of Anatomy, Faculty of Medicine, LMU Munich, 80331 Munich, Germany.ORCID 0000-0002-3859-2107
Jacqueline DinzeyInGeneron Inc., Houston, TX 77054, USA.ORCID 0000-0002-6688-5919
Ashley HillInGeneron Inc., Houston, TX 77054, USA.
Katie J SikesPreclinical Surgical Research Laboratory, Department of Clinical Sciences, C. Wayne McIlwraith Translational Medicine Institute, Colorado State University, Fort Collins, CO 80523, USA.ORCID 0000-0002-3750-4777
Lindsey H BurtonPreclinical Surgical Research Laboratory, Department of Clinical Sciences, C. Wayne McIlwraith Translational Medicine Institute, Colorado State University, Fort Collins, CO 80523, USA.ORCID 0000-0002-8791-0239
Jeremiah EasleyPreclinical Surgical Research Laboratory, Department of Clinical Sciences, C. Wayne McIlwraith Translational Medicine Institute, Colorado State University, Fort Collins, CO 80523, USA.
Holly L StewartPreclinical Surgical Research Laboratory, Department of Clinical Sciences, C. Wayne McIlwraith Translational Medicine Institute, Colorado State University, Fort Collins, CO 80523, USA.
Christian M PuttlitzOrthopaedic Bioengineering Research Laboratory, Department of Mechanical Engineering, Colorado State University, Fort Collins, CO 80524, USA.
Benjamin C GadomskiOrthopaedic Bioengineering Research Laboratory, Department of Mechanical Engineering, Colorado State University, Fort Collins, CO 80524, USA.ORCID 0000-0003-1434-0551
Kevin M LabusOrthopaedic Bioengineering Research Laboratory, Department of Mechanical Engineering, Colorado State University, Fort Collins, CO 80524, USA.ORCID 0000-0003-2072-6565
David A PearceDepartment of Pediatrics, Sanford School of Medicine, University of South Dakota, Sioux Falls, SD 57105, USA.
Nicola MaffulliDepartment of Trauma and Orthopaedic Surgery, Faculty of Medicine and Psychology, University La Sapienza, 00185 Roma, Italy.ORCID 0000-0002-5327-3702
Eckhard U AltIsarKlinikum, 80331 Munich, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Current treatment strategies for partial tendon tears often lack the capacity to promote true tissue regeneration and improve long-term clinical outcomes. This study tested the hypothesis that treatment of a partial defect in the rabbit common calcaneus tendon (CCT) with uncultured, unmodified, autologous, adipose-derived regenerative cells (UA-ADRCs) enables regenerative healing without scar formation. A full-thickness, 3 mm defect was produced in the midsubstance of the right gastrocnemius tendon, a component of the CCT, in adult female New Zealand white rabbits. Animals received either an injection of 28.3 × 10

Indexed as

Achilles TendonAdipose TissueBiomechanical PhenomenaRegenerationTendon InjuriesAnimalsElasticityFemaleRabbitsTendonsTransplantation, AutologousViscosityWound Healinganimal modelpartial tendon tearsstem cellsstromal vascular fractiontissue regenerationUA-ADRCS

Identifiers

PMID40725049
PMCPMC12295928

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.