Evidence map›Paper›PMID 40725031›Full record

ArticleInternational journal of molecular sciences2025

Platelet-Rich Plasma (PRP) Mitigates Silver Nanoparticle (AgNP)-Induced Pulmonary Fibrosis via iNOS/CD68/CASP3/TWIST1 Regulation: An Experimental Study and Bioinformatics Analysis.

Shaimaa R Abdelmohsen, Ranya M Abdelgalil, Asmaa M Elmaghraby, Amira M Negm, Reham Hammad, Eleni K Efthimiadou, Sara Seriah, Hekmat M El Magdoub, Hemat Elariny, Islam Farrag and 7 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Shaimaa R AbdelmohsenAnatomy & Embryology Department, Faculty of Medicine (for Girls), Al-Azhar University, Nasr City 11754, Cairo, Egypt.ORCID 0000-0002-9825-0694
Ranya M AbdelgalilAnatomy & Embryology Department, Faculty of Medicine (for Girls), Al-Azhar University, Nasr City 11754, Cairo, Egypt.
Asmaa M ElmaghrabyHistology Department, Faculty of Medicine (for Girls), Al-Azhar University, Nasr City 11754, Cairo, Egypt.
Amira M NegmPhysiology Department, Faculty of Medicine (for Girls), Al-Azhar University, Nasr City 11754, Cairo, Egypt.ORCID 0009-0000-7293-3430
Reham HammadClinical Pathology Department, Faculty of Medicine (for Girls), Al-Azhar University, Nasr City 11754, Cairo, Egypt.ORCID 0000-0002-8967-9106
Eleni K EfthimiadouInstitute of Nanoscience and Nanotechnology, National Center for Scientific Research "Demokritos", 15341 Athens, Greece.ORCID 0000-0002-6293-7881
Sara SeriahInstitute of Nanoscience and Nanotechnology, National Center for Scientific Research "Demokritos", 15341 Athens, Greece.ORCID 0000-0002-2642-4894
Hekmat M El MagdoubBiochemistry Department, Faculty of Pharmacy, Misr International University, Cairo 19648, Egypt.ORCID 0000-0001-5742-6713
Hemat ElarinyDepartment of Pharmacology and Toxicology, College of Pharmacy, University of Hail (UoH), Hail 81481, Saudi Arabia.
Islam FarragForensic Medicine and Clinical Toxicology Department, Faculty of Medicine (for Girls), Al-Azhar University, Nasr City 11754, Cairo, Egypt.ORCID 0000-0001-5295-5253
Nahla El ShenawyDepartment of Zoology and Entomology, Faculty of Science (for Girls), Al-Azhar University, Nasr City 11754, Cairo, Egypt.
Doaa AbdelrahamanForensic Medicine and Clinical Toxicology Department, Faculty of Medicine (for Girls), Al-Azhar University, Nasr City 11754, Cairo, Egypt.
Hussain AlmalkiDepartment of Chemistry, University College in Al-Qunfudah, Umm Al-Qura University, Makkah Al-Mukarramah 1109, Saudi Arabia.ORCID 0000-0002-0520-2643
Ahmed A AskarBotany and Microbiology Department, Faculty of Science (Boys), Al-Azhar University, Nasr City 11884, Cairo, Egypt.
Marwa M El-MoselyPathology Department, Faculty of Medicine, Zagazig University, Zagazig 44519, Al-Sharqiya, Egypt.ORCID 0000-0002-5349-7087
Fatma El Zahraa Abd El HakamPharmacology Department, Faculty of Medicine (for Girls), Al-Azhar University, Nasr City 11754, Cairo, Egypt.ORCID 0000-0001-9401-4996
Nadia M HamdyBiochemistry Department, Faculty of Pharmacy, Ain Shams University, Abassia 11566, Cairo, Egypt.ORCID 0000-0003-2105-107X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Platelet-rich plasma (PRP) has become an increasingly valuable biologic approach for personalized regenerative medicine because of its potent anti-inflammatory/healing effects. It is thought to be an excellent source of growth factors that can promote tissue healing and lessen fibrosis. Although this treatment has demonstrated effectiveness in numerous disease areas, its impact on pulmonary fibrosis (PF) caused by silver nanoparticles (AgNPs) via its antiapoptotic effects remains to be explored. AgNPs were synthesized biologically by

Indexed as

Metal NanoparticlesPlatelet-Rich PlasmaPulmonary FibrosisSilverAnimalsAntigens, CDAntigens, Differentiation, MyelomonocyticCaspase 3CD68 MoleculeComputational BiologyMaleNitric Oxide Synthase Type IIRatsRats, WistarTwist-Related Protein 1Antigens, CDAntigens, Differentiation, MyelomonocyticCasp3 protein, ratCaspase 3CD68 MoleculeCD68 protein, ratNitric Oxide Synthase Type IINos2 protein, ratSilverTwist-Related Protein 1caspase 3CD68iNOS (NOS2)in silico/bioinformatics analysislung/pulmonary fibrosis (PF)platelet-rich plasma (PRP)silver nanoparticles (AgNPs)TWIST1

Identifiers

PMID40725031
PMCPMC12294963

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.