Evidence map›Paper›PMID 40724987›Full record

ArticleInternational journal of molecular sciences2025

Genotype-Phenotype Correlation of TNF-α (-238, rs361525) and Cystatin C for Early Detection of Sepsis-Associated AKI and Its Severity in Critically Ill Neonates.

Shimaa Abdelsattar, Hiba S Al-Amodi, Mahmoud Nazih, Eman H M Salem, Rasha G Mostafa, Shymaa S Menshawy, Amany A El-Banna, Basma M Abdelgawad, Omnia S Nabih, Yasmin Mohsen and 6 more

Abstract read
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Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Shimaa AbdelsattarClinical Biochemistry and Molecular Diagnostics Department, National Liver Institute, Menofia University, Menofia 32511, Egypt.ORCID 0000-0002-3993-5378
Hiba S Al-AmodiBiochemistry Department, Faculty of Medicine, Umm Al-Qura University, Makkah 21955, Saudi Arabia.ORCID 0000-0003-1865-0004
Mahmoud NazihAl Ryada University for Science and Technology (RST), ElMehwar ElMarkazy-2, Cairo-Alex Desert RD K92, Sadat City 16504, Egypt.
Eman H M SalemDepartment of Medical Microbiology and Immunology, Faculty of Medicine, Menofia University, Menoufia 32511, Egypt.
Rasha G MostafaDepartment of Medical Microbiology and Immunology, Faculty of Medicine, Menofia University, Menoufia 32511, Egypt.
Shymaa S MenshawyPediatrics Department, Faculty of Medicine, Menoufia University, Menoufia 32511, Egypt.
Amany A El-BannaPediatrics Department, Faculty of Medicine, Menoufia University, Menoufia 32511, Egypt.ORCID 0000-0003-3599-1425
Basma M AbdelgawadFaculty of Medicine, Menoufia National University, Menoufia 32511, Egypt.
Omnia S NabihClinical Pathology Department, National Liver Institute, Menofia University, Shebin El-Kom 32511, Egypt.
Yasmin MohsenClinical Pathology Department, National Liver Institute, Menofia University, Shebin El-Kom 32511, Egypt.
Elaf AbozeidClinical Pathology Department, National Liver Institute, Menofia University, Shebin El-Kom 32511, Egypt.
Mai El-Sayad Abd El-HamidPediatrics Department, Faculty of Medicine, Menoufia University, Menoufia 32511, Egypt.
Nabil A ShomanDepartment of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Ahram Canadian University, Giza 12451, Egypt.ORCID 0000-0002-2817-645X
Naglaa Abdelmawgoud AhmedCommunity Health Nursing Department, Faculty of Nursing, Menoufia University, Shebin El-Kom 32511, Egypt.ORCID 0000-0001-7267-263X
Mai Mohamed NabilMedical Biochemistry Department, Faculty of Medicine, Ain Shams University, Cairo 11566, Egypt.ORCID 0000-0002-6251-5427
Dalia Abdel-Wahab MohamedMedical Biochemistry Department, Faculty of Medicine, Ain Shams University, Cairo 11566, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sepsis-associated acute kidney injury (S-AKI) represents a significant health problem associated with adverse outcomes. Our study aimed to assess the value of serum cystatin-C (sCysC) and TNF-α (rs361525) in combination for diagnosing S-AKI patients and predicting their adverse outcomes. The study included 100 critically ill neonates and 100 controls. Patients were categorized into an S-AKI group and a non-AKI group. TNF-α (-238, rs361525) genotyping was performed using RT-PCR, and sCysC was assessed using ELISA. Our study showed a fundamental difference in the genotype frequencies of TNF-α (-238, rs361525) and SNP between S-AKI and non-AKI patients. Furthermore, there was a significant relationship between cystatin C and TNF-α (-238, rs361525), where cystatin C was higher in patients with AA alleles than in patients with GA and GG alleles. Combining GA + AA genotypes with elevated serum cystatin-C levels can serve as a potential diagnostic and prognostic biomarker for AKI development in this population. The GA/AA genotypes independently predicted S-AKI risk (OR = 6.64,

Indexed as

Acute Kidney InjuryCystatin CSepsisTumor Necrosis Factor-alphaAllelesBiomarkersCase-Control StudiesCritical IllnessEarly DiagnosisFemaleGenetic Association StudiesGenotypeHumansInfant, NewbornMalePolymorphism, Single NucleotideBiomarkersCST3 protein, humanCystatin CTumor Necrosis Factor-alphaacute kidney injurycystatin Csepsis-associatedserum creatininetumor necrotizing factor-alpha

Identifiers

PMID40724987
PMCPMC12295153

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.