Long-Term Hypoxia Upregulates Wnt and TGFβ1 Signaling in Eccrine Sweat Gland Cells In Vitro.

Yanlin Lyu, Hiroko Kato, Qianwen Luo, Naoya Otani, Tateki Kubo, Kiyotoshi Sekiguchi, Fumitaka Fujita

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

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0citing papers in PubMed

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yanlin LyuLaboratory of Advanced Cosmetic Science, Graduate School of Pharmaceutical Sciences, The University of Osaka, Yamada-oka, Suita 565-0871, Osaka, Japan.

Hiroko KatoLaboratory of Advanced Cosmetic Science, Graduate School of Pharmaceutical Sciences, The University of Osaka, Yamada-oka, Suita 565-0871, Osaka, Japan.ORCID 0000-0002-2618-5539

Qianwen LuoLaboratory of Advanced Cosmetic Science, Graduate School of Pharmaceutical Sciences, The University of Osaka, Yamada-oka, Suita 565-0871, Osaka, Japan.

Naoya OtaniThe Department of Plastic Surgery, Graduate School of Medicine, The University of Osaka, Yamada-oka, Suita 565-0871, Osaka, Japan.

Tateki KuboThe Department of Plastic Surgery, Graduate School of Medicine, The University of Osaka, Yamada-oka, Suita 565-0871, Osaka, Japan.

Kiyotoshi SekiguchiDivision for Matrixome Research and Application, Institute for Protein Research, The University of Osaka, Yamada-oka, Suita 565-0871, Osaka, Japan.

Fumitaka FujitaLaboratory of Advanced Cosmetic Science, Graduate School of Pharmaceutical Sciences, The University of Osaka, Yamada-oka, Suita 565-0871, Osaka, Japan.

Funding

Japan Society for the Promotion of Science 23721401Japan Society for the Promotion of Science 25K14836Mochida Memorial Foundation For Medical And Pharmaceutical Research noneNaito Foundation none

6 · The paper itself

Abstract

Eccrine sweat glands play a vital role in human thermoregulation; however, their self-repair function is minimal. Therefore, developing methods to regenerate and improve sweat gland function that use cultured sweat gland cells presents an urgent issue. The tissue microenvironment, especially hypoxic niches, essentially maintain cell stemness, highlighting the importance of oxygen concentration in the culture environment. Therefore, we evaluated the effects of different oxygen environments on human sweat glands and their regulatory mechanisms. Human eccrine sweat glands express HIF-1α and HIF-2α, suggesting that they respond to hypoxia in vivo. Primary human-derived eccrine sweat gland cells were cultured for two weeks using the spheroid culture method at 0.5%, 2%, 10%, and 21% O

Indexed as

Eccrine GlandsTransforming Growth Factor beta1Wnt Signaling PathwayBasic Helix-Loop-Helix ProteinsCell HypoxiaCells, CulturedEndothelial PAS Domain-Containing Protein 1HumansHypoxia-Inducible Factor 1, alpha SubunitOxygenUp-RegulationBasic Helix-Loop-Helix ProteinsEndothelial PAS Domain-Containing Protein 1HIF1A protein, humanHypoxia-Inducible Factor 1, alpha SubunitOxygenTGFB1 protein, humanTransforming Growth Factor beta1hypoxiastem cellsweat glandTGFβ1 signalingWnt signaling

Identifiers

PMID40724920

DOI10.3390/ijms26146664

PMCPMC12294486

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.