Evidence map›Paper›PMID 40724913›Full record

ArticleInternational journal of molecular sciences2025

Kaempferol Alleviates Carbon Tetrachloride-Induced Liver Fibrosis in Mice by Regulating Intestinal Short-Chain Fatty Acids.

Siqi Zhang, Fei Tang, Zhe Zhou, Linhui Li, Yang Tang, Kaiwen Fu, Yang Tan, Ling Li

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Modulation of NF-κB and cytokine signaling byFrontiers in pharmacology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Siqi ZhangHunan Key Laboratory of Integrated Chinese and Western Medicine for Prevention and Treatment of Heart and Brain Diseases, Hunan University of Chinese Medicine, Changsha 410208, China.
Fei TangCollege of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China.
Zhe ZhouCollege of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China.
Linhui LiCollege of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China.
Yang TangCollege of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China.
Kaiwen FuCollege of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China.
Yang TanCollege of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China.ORCID 0000-0002-4834-6292
Ling LiCollege of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China.

Funding

National Key Laboratory Cultivation Base of Chinese Medicinal Powder & Innovative Medicinal Jointly Established by Province and Ministry 23PTKF1003
6 · The paper itself

Abstract

Liver fibrosis remains a critical health concern with limited therapeutic options. Kaempferol (Kae) is a natural flavonoid widely present in natural plants, yet its role in modulating gut-liver axis interactions during fibrosis is unexplored. This study investigates the hepatoprotective effects of Kae on alleviating carbon tetrachloride (CCl

Indexed as

Fatty Acids, VolatileKaempferolsLiver CirrhosisAnimalsCarbon TetrachlorideDisease Models, AnimalGastrointestinal MicrobiomeHeme Oxygenase-1HepatocytesKelch-Like ECH-Associated Protein 1LiverMaleMiceMice, Inbred C57BLNF-E2-Related Factor 2Oxidative StressCarbon TetrachlorideFatty Acids, VolatileHeme Oxygenase-1kaempferolKaempferolsKelch-Like ECH-Associated Protein 1Nfe2l2 protein, mouseNF-E2-Related Factor 2CCl4gut microbiotakaempferolliver fibrosismiceoxidative damageshort-chain fatty acids

Identifiers

PMID40724913
PMCPMC12294276

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.