Evidence map›Paper›PMID 40724879›Full record

ArticleInternational journal of molecular sciences2025

Comparing DNA Methylation Landscapes in Peripheral Blood from Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Long COVID Patients.

Katie Peppercorn, Sayan Sharma, Christina D Edgar, Peter A Stockwell, Euan J Rodger, Aniruddha Chatterjee, Warren P Tate

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Katie PeppercornDepartment of Biochemistry, School of Biomedical Sciences, University of Otago, Dunedin 9016, New Zealand.ORCID 0009-0007-6072-5926
Sayan SharmaDepartment of Pathology, Dunedin School of Medicine, University of Otago, Dunedin 9016, New Zealand.ORCID 0009-0005-9538-3415
Christina D EdgarDepartment of Biochemistry, School of Biomedical Sciences, University of Otago, Dunedin 9016, New Zealand.
Peter A StockwellDepartment of Pathology, Dunedin School of Medicine, University of Otago, Dunedin 9016, New Zealand.ORCID 0000-0002-2145-3493
Euan J RodgerDepartment of Pathology, Dunedin School of Medicine, University of Otago, Dunedin 9016, New Zealand.ORCID 0000-0002-9615-5896
Aniruddha ChatterjeeDepartment of Pathology, Dunedin School of Medicine, University of Otago, Dunedin 9016, New Zealand.ORCID 0000-0001-7276-2248
Warren P TateDepartment of Pathology, Dunedin School of Medicine, University of Otago, Dunedin 9016, New Zealand.ORCID 0000-0002-6971-7734

Funding

ANZMES no numberBrain Research New Zealand no numberBrain Research New Zealand no number givenPrivate donations no numbers
6 · The paper itself

Abstract

Post-viral conditions, Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Long COVID (LC), share > 95% of their symptoms, but the connection between disturbances in their underlying molecular biology is unclear. This study investigates DNA methylation patterns in peripheral blood mononuclear cells (PBMC) from patients with ME/CFS, LC, and healthy controls (HC). Reduced Representation Bisulphite Sequencing (RRBS) was applied to the DNA of age- and sex-matched cohorts: ME/CFS (

Indexed as

COVID-19DNA MethylationFatigue Syndrome, ChronicAdultCase-Control StudiesEpigenesis, GeneticFemaleHumansLeukocytes, MononuclearMaleMiddle AgedPrincipal Component AnalysisSARS-CoV-2differentially methylated fragmentsDNA methylationhypermethylationhypomethylationlong COVIDMyalgic Encephalomyelitis/Chronic Fatigue Syndromeperipheral blood mononuclear cells

Identifiers

PMID40724879
PMCPMC12294161

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.