Transcriptomic Alterations of Canine Histiocytic Sarcoma Cells in Response to Different Stressors.

Thanaporn Asawapattanakul, Klaus Schughart, Maren von Köckritz-Blickwede, Federico Armando, Peter Claus, Wolfgang Baumgärtner, Christina Puff

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In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Thanaporn AsawapattanakulDepartment of Pathology, University of Veterinary Medicine Hannover, 30559 Hannover, Germany.ORCID 0000-0002-7179-0340

Klaus SchughartInstitute of Virology Münster, University of Münster, 48149 Münster, Germany.ORCID 0000-0002-6824-7523

Maren von Köckritz-BlickwedeInstitute of Biochemistry, University of Veterinary Medicine Hannover, 30559 Hannover, Germany.ORCID 0000-0001-7712-9767

Federico ArmandoDepartment of Pathology, University of Veterinary Medicine Hannover, 30559 Hannover, Germany.ORCID 0000-0002-2578-4409

Peter ClausCenter for Systems Neuroscience (ZSN), 30559 Hannover, Germany.ORCID 0000-0003-3824-9445

Wolfgang BaumgärtnerDepartment of Pathology, University of Veterinary Medicine Hannover, 30559 Hannover, Germany.ORCID 0000-0001-8151-5644

Christina PuffDepartment of Pathology, University of Veterinary Medicine Hannover, 30559 Hannover, Germany.ORCID 0000-0002-2592-6868

Funding

Deutsche Forschungsgemeinschaft 398066876/GRK 2485/2, Research Training Group VIPERHelmholtz Association of German Research Centres Program Infection and ImmunityThe Royal Thai Governmant Scholarship

6 · The paper itself

Abstract

Canine histiocytic sarcoma (HS) is a rare tumor with a poor prognosis. Rapid tumor growth often causes central hypoxia and starvation, impacting tumor progression. In the present study, HS cells were cultured under hypoxia and starvation for 1 and 3 days, simulating intermediate and central tumor zones, respectively. Cells were counted at each time point, followed by RNAseq analysis. Only hypoxia significantly reduced the cell number (

Indexed as

Dog DiseasesGene Expression Regulation, NeoplasticHistiocytic SarcomaTranscriptomeAnimalsCell HypoxiaCell Line, TumorDogsGene Expression ProfilinghypoxiametabolismRNA sequencingstarvationstresstumor zones

Identifiers

PMID40724877

DOI10.3390/ijms26146629

PMCPMC12294338

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.