Evidence map›Paper›PMID 40724856›Full record

ArticleInternational journal of molecular sciences2025

Anti-Obesity and Metabolic Effects of Forskolin in Obese C57BL/6J Mice.

Mehrnaz Abbasi, Fang Zhou, Ngoc Kim Ly, Austin Taylor, Qiaobin Hu, Jinhua Chi, Haiwei Gu, Shu Wang

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Adipocyte Browning: A Promising Avenue in Anti-Obesity Therapy.International journal of molecular sciences · 2026
    Review
  2. Review
  3. Ciliary-Mediated Mechanotransduction in Skeletal Development and Diseases.Results and problems in cell differentiation · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mehrnaz AbbasiCollege of Health Solutions, Arizona State University, Phoenix, AZ 85004, USA.ORCID 0000-0003-4287-2133
Fang ZhouCollege of Health Solutions, Arizona State University, Phoenix, AZ 85004, USA.ORCID 0000-0002-1982-2982
Ngoc Kim LyCollege of Health Solutions, Arizona State University, Phoenix, AZ 85004, USA.
Austin TaylorCollege of Health Solutions, Arizona State University, Phoenix, AZ 85004, USA.
Qiaobin HuCollege of Health Solutions, Arizona State University, Phoenix, AZ 85004, USA.
Jinhua ChiCollege of Health Solutions, Arizona State University, Phoenix, AZ 85004, USA.
Haiwei GuCollege of Health Solutions, Arizona State University, Phoenix, AZ 85004, USA.
Shu WangCollege of Health Solutions, Arizona State University, Phoenix, AZ 85004, USA.ORCID 0000-0001-8078-9942

Funding

Browning White Adipose Tissue for Diabetes TreatmentR15AT010395 · NCCIH · TEXAS TECH UNIVERSITY · PI DHURANDHAR, NIKHIL V · 2019 to 2019
$436k
American Heart Association 19AIREA34480011NCCIH NIH HHS 1R15AT010395NCCIH NIH HHS R15 AT010395
6 · The paper itself

Abstract

Forskolin (FSK) induces the browning of white adipose tissue (WAT) through the activation of adenylate cyclase (AC) and cyclic adenosine monophosphate (cAMP) generation. When administered intravenously or orally, FSK undergoes significant metabolism and accumulation in the liver and other tissues, resulting in high side effects and low anti-obesity effects due to trivial amounts reaching WAT. This study examines the potential anti-obesity and metabolic effects of the inguinal WAT (IWAT) delivery of FSK in high-fat diet-induced C57BL/6J obese mice. Mice received one of the following treatments twice weekly for 4 weeks: 1. Control into both IWAT depots (Con

Indexed as

Anti-Obesity AgentsColforsinObesityAdipose Tissue, WhiteAnimalsBlood GlucoseDiet, High-FatInsulinLiverMaleMiceMice, Inbred C57BLMice, ObeseUncoupling Protein 1Anti-Obesity AgentsBlood GlucoseColforsinInsulinUncoupling Protein 1forskolinmetabolic healthobesitysubcutaneous WAT deliverywhite adipose tissue browning

Identifiers

PMID40724856
PMCPMC12295497

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.