Evidence map›Paper›PMID 40724834›Full record

ArticleInternational journal of molecular sciences2025

Genetic Association of

Chang Soo Ryu, Ji Hyang Kim, Eun Ju Ko, Hyeon Woo Park, Jae Hyun Lee, Ji Eun Shin, Young Ran Kim, Eun Hee Ahn, Nam Keun Kim

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chang Soo RyuDepartment of Life Science, Graduate School, CHA University, 335 Pangyo-ro, Bundang-gu, Seongnam 13488, Republic of Korea.
Ji Hyang KimDepartment of Obstetrics and Gynecology, CHA Bundang Medical Center, School of Medicine, CHA University, 59 Yatap-ro, Bundang-gu, Seongnam 13496, Republic of Korea.ORCID 0000-0002-9864-9777
Eun Ju KoDepartment of Life Science, Graduate School, CHA University, 335 Pangyo-ro, Bundang-gu, Seongnam 13488, Republic of Korea.
Hyeon Woo ParkDepartment of Life Science, Graduate School, CHA University, 335 Pangyo-ro, Bundang-gu, Seongnam 13488, Republic of Korea.
Jae Hyun LeeDepartment of Life Science, Graduate School, CHA University, 335 Pangyo-ro, Bundang-gu, Seongnam 13488, Republic of Korea.
Ji Eun ShinDepartment of Obstetrics and Gynecology, CHA Bundang Medical Center, School of Medicine, CHA University, 59 Yatap-ro, Bundang-gu, Seongnam 13496, Republic of Korea.
Young Ran KimDepartment of Obstetrics and Gynecology, CHA Bundang Medical Center, School of Medicine, CHA University, 59 Yatap-ro, Bundang-gu, Seongnam 13496, Republic of Korea.
Eun Hee AhnDepartment of Obstetrics and Gynecology, CHA Bundang Medical Center, School of Medicine, CHA University, 59 Yatap-ro, Bundang-gu, Seongnam 13496, Republic of Korea.
Nam Keun KimDepartment of Life Science, Graduate School, CHA University, 335 Pangyo-ro, Bundang-gu, Seongnam 13488, Republic of Korea.ORCID 0000-0003-0541-3528

Funding

Korea Health Industry Development Institute KHIDI - HR22C1605 to J.H.K.National Research Foundation of Korea NRF-2022R1F1A1064169 to N.K.K; NRF-2022R1F1A1074986 to Y.R.K and RS-2023-00246879 to E.H.A
6 · The paper itself

Abstract

Recurrent pregnancy loss (RPL) is defined as the occurrence of two or more consecutive pregnancy losses before 20 weeks of gestation, encompassing both embryonic and fetal losses. Although previous studies have provided substantial insights into RPL, the causes in many cases remain unexplained. This lack of information has prompted continued investigation into various risk factors, including those identified through next-generation sequencing (NGS). In the present study, whole-exome sequencing (WES) was used to identify genes potentially associated with RPL and infertility, which may serve as novel biomarkers. Confirmation of the association between these genetic variants and RPL may help to develop functional biomarkers for early diagnosis. The findings revealed that the

Indexed as

Abortion, HabitualGenetic Predisposition to DiseaseMucin-2Polymorphism, Single NucleotideAdultAllelesCase-Control StudiesExome SequencingFemaleGenetic Association StudiesHumansPregnancyMUC2 protein, humanMucin-2biomarkergenetic variantrecurrent pregnancy losswhole-exome sequencing

Identifiers

PMID40724834
PMCPMC12294619

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.