Evidence map›Paper›PMID 40724821›Full record

ArticleInternational journal of molecular sciences2025

Differences in Tissue Copper and Zinc Content Between Normal Livers and Those with Cirrhosis with or Without Hepatocellular Carcinoma.

Simona Parisse, Giulia Andreani, Monica Mischitelli, Alessandra Gianoncelli, Emil Malucelli, Michela Fratini, Flaminia Ferri, Maria Carlucci, Quirino Lai, Andrea Ascione and 5 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Simona ParisseDepartment of Translational and Precision Medicine, "Sapienza" University of Rome, Viale dell'Università 37, 00185 Rome, Italy.ORCID 0000-0002-9953-009X
Giulia AndreaniDepartment of Veterinary Medical Sciences, Alma Mater Studiorum-University of Bologna, Via Tolara di Sopra 50, 40064 Ozzano dell'Emilia, Bologna, Italy.ORCID 0000-0003-0509-1952
Monica MischitelliDepartment of Translational and Precision Medicine, "Sapienza" University of Rome, Viale dell'Università 37, 00185 Rome, Italy.ORCID 0000-0003-1865-4101
Alessandra GianoncelliElettra-Sincrotrone Trieste, Strada Statale 14 km 163,5 in AREA Science Park, Basovizza, 34149 Trieste, Italy.ORCID 0000-0002-2457-3618
Emil MalucelliDepartment of Pharmacy and Biotechnology, University of Bologna, 40126 Bologna, Italy.ORCID 0000-0002-1077-0098
Michela FratiniDepartment of Physics, CNR-Nanotec (Rome Unit) c/o, Sapienza University of Rome, Piazzale Aldo Moro 7, 00185 Rome, Italy.
Flaminia FerriDepartment of Translational and Precision Medicine, "Sapienza" University of Rome, Viale dell'Università 37, 00185 Rome, Italy.ORCID 0000-0001-8553-5589
Maria CarlucciDepartment of Translational and Precision Medicine, "Sapienza" University of Rome, Viale dell'Università 37, 00185 Rome, Italy.
Quirino LaiGeneral Surgery and Organ Transplantation Unit, "Sapienza" University of Rome, Viale del Policlinico 155, 00161 Rome, Italy.ORCID 0000-0003-1487-3235
Andrea AscioneDepartment of Experimental Medicine, "Sapienza" University of Rome, Viale Regina Elena 324, 00161 Rome, Italy.ORCID 0000-0002-4253-3193
Gianluca MenniniGeneral Surgery and Organ Transplantation Unit, "Sapienza" University of Rome, Viale del Policlinico 155, 00161 Rome, Italy.
Massimo RossiGeneral Surgery and Organ Transplantation Unit, "Sapienza" University of Rome, Viale del Policlinico 155, 00161 Rome, Italy.
Stefano IottiDepartment of Pharmacy and Biotechnology, University of Bologna, 40126 Bologna, Italy.ORCID 0000-0003-1426-6400
Gloria IsaniDepartment of Veterinary Medical Sciences, Alma Mater Studiorum-University of Bologna, Via Tolara di Sopra 50, 40064 Ozzano dell'Emilia, Bologna, Italy.ORCID 0000-0002-3911-8749
Stefano Ginanni CorradiniDepartment of Translational and Precision Medicine, "Sapienza" University of Rome, Viale dell'Università 37, 00185 Rome, Italy.ORCID 0000-0002-0839-1961

Funding

Sapienza University of Rome RP11916B4197BA03
6 · The paper itself

Abstract

This study aimed to compare the contents of copper (Cu), zinc (Zn), magnesium (Mg), and iron (Fe) in healthy liver tissue from deceased liver donors (DGs), in cirrhotic tissue from patients without (CIR) or with hepatocellular carcinoma (CIR-HCC) and in HCC tissue from the latter patients. Liver tissue samples were obtained from cirrhotic liver transplant recipients, with (

Indexed as

Carcinoma, HepatocellularCopperLiverLiver CirrhosisLiver NeoplasmsZincAdultAgedFemaleHumansIronMagnesiumMaleMiddle AgedCopperIronMagnesiumZincatomic absorptioncancercirrhosiscopperhepatocellular carcinomaliverliver transplantmagnesiummetalszinc

Identifiers

PMID40724821
PMCPMC12294540

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.