Evidence map›Paper›PMID 40724799›Full record

ArticleInternational journal of molecular sciences2025

Lower Initial Insulin-like Growth Factor-Binding Protein-3 Concentrations May Reflect Immune Suppression and Predict Increased Risk of Sepsis-Related Mortality.

Filippo Mearelli, Alessio Nunnari, Federica Chitti, Annalisa Rombini, Alessandra Macor, Donatella Denora, Luca Messana, Marianna Scardino, Ilaria Martini, Giulia Bolzan and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Filippo MearelliUnit of Internal Medicine, Clinica Medica, Department of Medical Surgical and Health Sciences, University of Trieste, Strada di Fiume 447, 34100 Trieste, Italy.ORCID 0000-0002-5862-9077
Alessio NunnariUnit of Internal Medicine, Clinica Medica, Department of Medical Surgical and Health Sciences, University of Trieste, Strada di Fiume 447, 34100 Trieste, Italy.ORCID 0009-0001-8818-1322
Federica ChittiUnit of Internal Medicine, Clinica Medica, Department of Medical Surgical and Health Sciences, University of Trieste, Strada di Fiume 447, 34100 Trieste, Italy.
Annalisa RombiniUnit of Internal Medicine, Clinica Medica, Department of Medical Surgical and Health Sciences, University of Trieste, Strada di Fiume 447, 34100 Trieste, Italy.
Alessandra MacorUnit of Internal Medicine, Clinica Medica, Department of Medical Surgical and Health Sciences, University of Trieste, Strada di Fiume 447, 34100 Trieste, Italy.
Donatella DenoraUnit of Internal Medicine, Clinica Medica, Department of Medical Surgical and Health Sciences, University of Trieste, Strada di Fiume 447, 34100 Trieste, Italy.
Luca MessanaUnit of Internal Medicine, Clinica Medica, Department of Medical Surgical and Health Sciences, University of Trieste, Strada di Fiume 447, 34100 Trieste, Italy.
Marianna ScardinoUnit of Internal Medicine, Clinica Medica, Department of Medical Surgical and Health Sciences, University of Trieste, Strada di Fiume 447, 34100 Trieste, Italy.
Ilaria MartiniUnit of Internal Medicine, Clinica Medica, Department of Medical Surgical and Health Sciences, University of Trieste, Strada di Fiume 447, 34100 Trieste, Italy.
Giulia BolzanUnit of Internal Medicine, Clinica Medica, Department of Medical Surgical and Health Sciences, University of Trieste, Strada di Fiume 447, 34100 Trieste, Italy.
Francesca SpagnolUnit of Internal Medicine, Clinica Medica, Department of Medical Surgical and Health Sciences, University of Trieste, Strada di Fiume 447, 34100 Trieste, Italy.
Chiara CasarsaUnit of Internal Medicine, Clinica Medica, Department of Medical Surgical and Health Sciences, University of Trieste, Strada di Fiume 447, 34100 Trieste, Italy.
Nicola FiottiUnit of Internal Medicine, Clinica Medica, Department of Medical Surgical and Health Sciences, University of Trieste, Strada di Fiume 447, 34100 Trieste, Italy.ORCID 0000-0001-8918-7622
Verena ZerbatoInfectious Diseases Unit, Clinical Departement of Medical, Surgical, and Health Sciences, University Hospital (ASUGI), Piazzale dell'Ospedale n° 1, 34100 Trieste, Italy.ORCID 0000-0002-9204-032X
Stefano Di BellaInfectious Diseases Unit, Clinical Departement of Medical, Surgical, and Health Sciences, University Hospital (ASUGI), Piazzale dell'Ospedale n° 1, 34100 Trieste, Italy.ORCID 0000-0001-6121-7009
Carlo TasciniInfectious Diseases Unit, University Hospital (ASUFC), Via Pozzuolo n° 330, 33100 Udine, Italy.ORCID 0000-0001-9625-6024
Filippo Giorgio Di GirolamoUnit of Internal Medicine, Clinica Medica, Department of Medical Surgical and Health Sciences, University of Trieste, Strada di Fiume 447, 34100 Trieste, Italy.
Mariella SturmaUnit of Internal Medicine, Clinica Medica, Department of Medical Surgical and Health Sciences, University of Trieste, Strada di Fiume 447, 34100 Trieste, Italy.
Venera CostantinoMicrobiology Unit, University Hospital (ASUGI), Strada di Fiume n° 447, 34137 Trieste, Italy.ORCID 0009-0000-6529-5653
Gianni BioloUnit of Internal Medicine, Clinica Medica, Department of Medical Surgical and Health Sciences, University of Trieste, Strada di Fiume 447, 34100 Trieste, Italy.ORCID 0000-0002-6397-1598

Funding

European Union X-BRAIN.NET (grant number CUP: J93C23000690008. Code (UGOV): D70-RINTG23BIOLO_01
6 · The paper itself

Abstract

Insulin-like growth factor-binding protein-3 (IGFBP-3) plays a vital role in cellular growth, development, and survival. Incorporating IGFBP-3 into baseline prognostic evaluations may enhance the prediction of mortality in patients with sepsis. In this study, serum levels of IGFBP-3, C-reactive protein, procalcitonin, lactate, interleukin-6, and mid-regional pro-adrenomedullin were measured upon admission to the internal medicine unit (IMU) in 139 patients with microbiologically confirmed sepsis. The objectives were as follows: (1) to classify septic patient phenotypes based on optimal thresholds of independent prognostic biomarkers and (2) to evaluate whether these biomarkers improve the predictive accuracy of a clinical model (Model 1), which includes the clinical predictors of 1-year mortality. Age, sequential organ failure assessment (SOFA) score, multiple sources of infection, and IGFBP-3 levels independently predicted 1-year mortality. Patients with IGFBP-3 levels below 10.64 had significantly lower median body temperature (

Indexed as

Insulin-Like Growth Factor Binding Protein 3SepsisAgedAged, 80 and overBiomarkersC-Reactive ProteinFemaleHumansInsulin-Like PeptidesMaleMiddle AgedOrgan Dysfunction ScoresPrognosisRisk FactorsBiomarkersC-Reactive ProteinIGFBP3 protein, humanInsulin-Like Growth Factor Binding Protein 3Insulin-Like Peptidesgut dysfunctionimmune suppressioninsulin-like growth factorinsulin-like growth factor-binding protein-3interleukin-6lactatemid-regional pro-adrenomedullinprocalcitoninsepsis

Identifiers

PMID40724799
PMCPMC12294467

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.