Evidence map›Paper›PMID 40724631›Full record

ArticleLife (Basel, Switzerland)2025

Human Immune System Reconstitution in NOD/Shi-

Aleksey M Nagornykh, Marina A Tyumentseva, Aleksandr I Tyumentsev, Leonid A Fedotov, Konstantin S Karbyshev, Evgeniya A Orlova, Liliia N Volchkova, Lubov S Danilova, Andrey S Akinin, Vasiliy G Akimkin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Aleksey M NagornykhCentral Research Institute for Epidemiology of the Federal Service for Supervision of Consumer Rights Protection and Human Welfare, Moscow 111123, Russia.ORCID 0000-0002-8320-2999
Marina A TyumentsevaCentral Research Institute for Epidemiology of the Federal Service for Supervision of Consumer Rights Protection and Human Welfare, Moscow 111123, Russia.ORCID 0000-0002-3145-3702
Aleksandr I TyumentsevCentral Research Institute for Epidemiology of the Federal Service for Supervision of Consumer Rights Protection and Human Welfare, Moscow 111123, Russia.ORCID 0000-0003-0537-2586
Leonid A FedotovCentral Research Institute for Epidemiology of the Federal Service for Supervision of Consumer Rights Protection and Human Welfare, Moscow 111123, Russia.
Konstantin S KarbyshevCentral Research Institute for Epidemiology of the Federal Service for Supervision of Consumer Rights Protection and Human Welfare, Moscow 111123, Russia.ORCID 0000-0002-8992-4861
Evgeniya A OrlovaCentral Research Institute for Epidemiology of the Federal Service for Supervision of Consumer Rights Protection and Human Welfare, Moscow 111123, Russia.ORCID 0009-0002-2916-5899
Liliia N VolchkovaCentral Research Institute for Epidemiology of the Federal Service for Supervision of Consumer Rights Protection and Human Welfare, Moscow 111123, Russia.
Lubov S DanilovaCentral Research Institute for Epidemiology of the Federal Service for Supervision of Consumer Rights Protection and Human Welfare, Moscow 111123, Russia.
Andrey S AkininCentral Research Institute for Epidemiology of the Federal Service for Supervision of Consumer Rights Protection and Human Welfare, Moscow 111123, Russia.ORCID 0009-0007-4256-0435
Vasiliy G AkimkinCentral Research Institute for Epidemiology of the Federal Service for Supervision of Consumer Rights Protection and Human Welfare, Moscow 111123, Russia.ORCID 0000-0003-4228-9044

Funding

The Ministry of Science and Higher Education of the Russian Federation 075-15-2025-517
6 · The paper itself

Abstract

The main challenge after engraftment of human tissues to mice is the development of graft-versus-host disease. It often occurs in an acute form, which reduces the time frame for observations. This is especially important to take into account when planning long-term studies of chronic diseases such as HIV infection. In addition, in mice, even with a similar genotype but different origin, the interaction between the graft and the recipient's organism can manifest itself differently. We engrafted human immune cells in three different concentrations into immunodeficient NOD/Shi-

Indexed as

graft-versus-host diseaseHIVmouse modelperipheral blood mononuclear cellsT-helper cells

Identifiers

PMID40724631
PMCPMC12300024

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.