Evidence map›Paper›PMID 40724106›Full record

Trial reportInternational journal of environmental research and public health2025

The Nicotine Metabolite Ratio and Response to Smoking Cessation Treatment Among People Living with HIV Who Smoke in South Africa.

Chukwudi Keke, Limakatso Lebina, Katlego Motlhaoleng, Raymond Niaura, David Abrams, Ebrahim Variava, Nikhil Gupte, Jonathan E Golub, Neil A Martinson, Jessica L Elf

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in International journal of environmental research and public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chukwudi KekeDepartment of Environmental and Radiological Health Science, Colorado State University, Fort Collins, CO 80523, USA.ORCID 0009-0002-7224-6248
Limakatso LebinaAfrica Health Research Institute, Somkhele, Myeki 3935, South Africa.ORCID 0000-0001-6825-0573
Katlego MotlhaolengPerinatal HIV Research Unit (PHRU), University of the Witwatersrand, Johannesburg 2193, South Africa.ORCID 0000-0001-7644-1038
Raymond NiauraSchool of Global Public Health, New York University, New York, NY 10003, USA.ORCID 0000-0002-0856-3540
David AbramsSchool of Global Public Health, New York University, New York, NY 10003, USA.
Ebrahim VariavaKlerksdorp Tshepong Hospital Complex, Matlosana 2574, South Africa.
Nikhil GupteDepartment of Infectious Diseases, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
Jonathan E GolubDepartment of Infectious Diseases, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
Neil A MartinsonPerinatal HIV Research Unit (PHRU), University of the Witwatersrand, Johannesburg 2193, South Africa.
Jessica L ElfDepartment of Environmental and Radiological Health Science, Colorado State University, Fort Collins, CO 80523, USA.ORCID 0000-0002-4298-6395

Funding

College Research Council of the College of Veterinary Medicine and Biomedical Sciences at Colorado State University. N/ANational Institute on Drug Abuse of the National Institutes of Health R01DA030276
6 · The paper itself

Abstract

The nicotine metabolite ratio (NMR) has been informative in selecting treatment choices for nicotine dependence and increasing treatment efficacy in Western settings; however, the clinical utility of the NMR among smokers in low-resource settings remains unclear. Prospective analysis was conducted using data from a randomized controlled trial of smoking cessation among adults living with HIV, to examine the association between the NMR and response to smoking cessation treatment. NMR was assessed using bio-banked urine samples collected at baseline. Self-reported smoking at 6 months was verified using a urine cotinine test and exhaled breath carbon monoxide (CO). We found no associations between the NMR and smoking abstinence (adjusted risk ratio (aRR) = 0.82; 95% CI: 0.45, 1.49;

Indexed as

HIV InfectionsNicotineSmokingSmoking CessationAdultBreath TestsCarbon MonoxideCotinineFemaleHumansMaleMiddle AgedProspective StudiesSouth AfricaCarbon MonoxideCotinineNicotinebehavioral counselingbiomarkerHIVnicotine metabolite rationicotine replacement therapysmoking cessation

Identifiers

PMID40724106
PMCPMC12294352

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.