Oocyte Exposure to Low Levels of Triclosan Has a Significant Impact on Subsequent Embryo Physiology.

Vasiliki Papachristofi, Paul J McKeegan, Henry J Leese, Jeanette M Rotchell, Roger G Sturmey

Abstract read

In one paragraph

Article in International journal of environmental research and public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Vasiliki PapachristofiCentre for Biomedicine, Hull York Medical School, University of Hull, Hull HU6 7RX, UK.

Paul J McKeeganHull York Medical School, University of Hull, Hull HU6 7RX, UK.ORCID 0000-0002-5318-2317

Henry J LeeseCentre for Biomedicine, Hull York Medical School, University of Hull, Hull HU6 7RX, UK.

Jeanette M RotchellCollege of Health and Science, University of Lincoln, Lincoln LN6 7DQ, UK.ORCID 0000-0002-7371-6080

Roger G SturmeyCentre for Biomedicine, Hull York Medical School, University of Hull, Hull HU6 7RX, UK.ORCID 0000-0003-4423-5058

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Triclosan (TCS) is an antimicrobial agent in a wide range of health care products. It has been found in various human bodily fluids and is a potential reproductive toxicant. However, the effect of TCS on early embryo development in mammalian species is limited. We therefore asked whether exposure to TCS affects mammalian cumulus-oocyte complexes (COCs), and if so, whether the effects persist into the early embryo. COCs, isolated from abattoir-derived bovine ovaries, were exposed to two environmentally relevant doses of TCS (1 and 10 nM) during in vitro maturation. When exposed to 1 nM TCS during in vitro maturation, progesterone release from bovine oocytes was elevated. Furthermore, altered pyruvate metabolism and mitochondrial dysfunction were also observed; specifically, O

Indexed as

Anti-Infective Agents, LocalEmbryo, MammalianEmbryonic DevelopmentOocytesTriclosanAnimalsCattleCumulus CellsFemaleMitochondriaProgesteronePyruvic AcidAnti-Infective Agents, LocalProgesteronePyruvic AcidTriclosanembryo metabolismendocrine disrupting chemicalsoocyte metabolismtriclosan

Identifiers

PMID40724098

DOI10.3390/ijerph22071031

PMCPMC12294238

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.