Evidence map›Paper›PMID 40723937›Full record

ArticleAntibiotics (Basel, Switzerland)2025

Oral Administration of Heat-Killed Multi-Strain Probiotics Confers Durable Protection Against Antibiotic-Resistant Primary and Recurrent Urinary Tract Infections in a Murine Model.

Bo-Yuan Chen, Zhen-Shu Liu, Yu-Syuan Lin, Hsiao Chin Lin, Po-Wen Chen

Abstract read
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Bo-Yuan ChenDepartment of Veterinary Medicine, College of Veterinary Medicine, National Chung Hsing University, Taichung 40249, Taiwan.
Zhen-Shu LiuDepartment of Safety, Health and Environmental Engineering, Ming Chi University of Technology, New Taipei City 24301, Taiwan.ORCID 0000-0001-9480-4023
Yu-Syuan LinDepartment of Veterinary Medicine, College of Veterinary Medicine, National Chung Hsing University, Taichung 40249, Taiwan.
Hsiao Chin LinDepartment of Veterinary Medicine, College of Veterinary Medicine, National Chung Hsing University, Taichung 40249, Taiwan.
Po-Wen ChenDepartment of Veterinary Medicine, College of Veterinary Medicine, National Chung Hsing University, Taichung 40249, Taiwan.ORCID 0000-0003-1230-1532

Funding

Taiwan National Science and Technology Council grants 112-2313-B-005-037
6 · The paper itself

Abstract

Background/Objectives

methodsWe compared a multi-strain (seven-strain) versus a single-strain postbiotic in preventing

resultsBoth postbiotics significantly accelerated bacterial clearance in primary UTIs (

conclusionsThese findings demonstrate the superior efficacy of Postbiotic I in mitigating UTIs, with sustained protection post-treatment, supporting its potential as a long-term, non-antibiotic strategy. Additionally, our reproducible chronic UTI model, achieved through the co-inoculation of three uropathogens, provides a valuable tool for future research on chronic UTI pathogenesis and treatment.

Indexed as

antimicrobial resistanceheat-killed probioticlactic acid bacteriamice modelpostbioticrecurrent urinary tract infectionsuropathogenic Escherichia coli

Identifiers

PMID40723937
PMCPMC12291791

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.