Conditional Deletion of Translin/Trax in Dopaminergic Neurons Reveals No Impact on Psychostimulant Behaviors or Adiposity.

Yunlong Liu, Renkun Wu, Gaiyuan Geng, Helian Yang, Chunmiao Wang, Mengtian Ren, Xiuping Fu

Abstract read

In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yunlong LiuSchool of Life Sciences and School of Chemistry, Tiangong University, Tianjin 300387, China.ORCID 0000-0002-0185-9293

Renkun WuSchool of Life Sciences and School of Chemistry, Tiangong University, Tianjin 300387, China.

Gaiyuan GengSchool of Life Sciences and School of Chemistry, Tiangong University, Tianjin 300387, China.

Helian YangSchool of Life Sciences and School of Chemistry, Tiangong University, Tianjin 300387, China.

Chunmiao WangSchool of Life Sciences and School of Chemistry, Tiangong University, Tianjin 300387, China.

Mengtian RenSchool of Life Sciences and School of Chemistry, Tiangong University, Tianjin 300387, China.ORCID 0009-0008-6966-5146

Xiuping FuSchool of Life Sciences and School of Chemistry, Tiangong University, Tianjin 300387, China.ORCID 0000-0002-8699-9518

Funding

National Natural Science Foundation of China 32401009, 22407100 and 32371268

6 · The paper itself

Abstract

Despite the abundant expression of the microRNA-degrading Translin (TN)/Trax (TX) complex in midbrain dopaminergic (DA) neurons and its implication in neuropsychiatric disorders, its cell-autonomous roles in metabolic and behavioral responses remain unclear. To address this, we generated DA neuron-specific conditional knockout (cKO) mice for

Indexed as

AdiposityCentral Nervous System StimulantsDNA-Binding ProteinsDopaminergic NeuronsRNA-Binding ProteinsAmphetamineAnimalsBehavior, AnimalCocaineLocomotionMaleMiceMice, KnockoutAmphetamineCentral Nervous System StimulantsCocaineDNA-Binding ProteinsRNA-Binding Proteinsamphetaminecocainedopaminergic neuronsmicroRNAsTranslin/Trax

Identifiers

PMID40723911

DOI10.3390/biom15071040

PMCPMC12293684

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.