Evidence map›Paper›PMID 40723890›Full record

ArticleBiomolecules2025

Role of Oral Bacteria in Mediating Gemcitabine Resistance in Pancreatic Cancer.

Geng Xu, Yaling Jiang, Chen Sun, Bernd W Brandt, Kamran Nazmi, Luca Morelli, Giulia Lencioni, Elisa Giovannetti, Dongmei Deng

Abstract read
In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Review
  3. [The Oral Microbiome: Maintenance of Homeostasis, Disease Associations, and Mechanisms of Pathogenesis].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026
    Review
  4. Review
  5. IntratumoraliMeta · 2026
    Article
  6. Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Geng XuDepartment of Preventive Dentistry, Academic Center for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University Amsterdam, 1081 LA Amsterdam, The Netherlands.ORCID 0000-0002-4597-8729
Yaling JiangDepartment of Preventive Dentistry, Academic Center for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University Amsterdam, 1081 LA Amsterdam, The Netherlands.
Chen SunDepartment of Preventive Dentistry, Academic Center for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University Amsterdam, 1081 LA Amsterdam, The Netherlands.
Bernd W BrandtDepartment of Preventive Dentistry, Academic Center for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University Amsterdam, 1081 LA Amsterdam, The Netherlands.
Kamran NazmiDepartment of Oral Biochemistry, Academic Center for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University Amsterdam, 1081 LA Amsterdam, The Netherlands.
Luca MorelliGeneral Surgery Unit, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, 43, 56126 Pisa, Italy.ORCID 0000-0002-7742-9556
Giulia LencioniFondazione Pisana per la Scienza, San Giuliano Terme, 13, 56017 Pisa, Italy.ORCID 0009-0008-6521-337X
Elisa GiovannettiDepartment of Medical Oncology, Cancer Center Amsterdam, Amsterdam UMC, VU University Amsterdam, 1081 HV Amsterdam, The Netherlands.ORCID 0000-0002-7565-7504
Dongmei DengDepartment of Preventive Dentistry, Academic Center for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University Amsterdam, 1081 LA Amsterdam, The Netherlands.ORCID 0000-0003-3706-1678

Funding

AIRC-IG 24444Dutch Cancer Society KWF-15305Dutch Research Council OCENW.XS22.4.135PANOMIC grant Fondazione Pisa 2022 Fondazione Pisa 2022
6 · The paper itself

Abstract

Oral microbiota have been implicated in pancreatic ductal adenocarcinoma (PDAC) and may contribute to chemotherapy resistance. While previous studies attributed bacteria-induced resistance to indirect host modulation, recent findings suggest a direct mechanism.

Indexed as

Antimetabolites, AntineoplasticCarcinoma, Pancreatic DuctalDeoxycytidineDrug Resistance, NeoplasmMouthPancreatic NeoplasmsAggregatibacter actinomycetemcomitansCell Line, TumorCell ProliferationCytidine DeaminaseEscherichia coliGemcitabineHumansAntimetabolites, AntineoplasticCytidine DeaminaseDeoxycytidineGemcitabinecytidine deaminasedrug resistancegemcitabinehost microbial interactionsHPLCpancreatic cancer

Identifiers

PMID40723890
PMCPMC12293802

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.